Results 91 to 100 of about 3,314,194 (266)

IMMUNOLOGICAL PROFILE OF SEROUS OVARIAN CARCINOMA AND DUCTAL BREAST CARCINOMA

Паёми Сино
Objective: To evaluate the immunological profile of serous ovarian carcinoma and ductal breast carcinoma, as well as the activity of apoptotic markers as a prognostic factor of sensitivity to immunotherapy. Methods: The study included 53 patients with
Golovkin Ilya Olegovich, Aliev Kazim Alievich, Makalish Tatyana Pavlovna, Asanova Elvina Refatovna, Maksimova Polina Evgenievna, Zyablitskaya Evgeniya Yurievna   +5 more
doaj   +1 more source

Second‐order trace formulas

Mathematische Nachrichten
AbstractKoplienko [Sib. Mat. Zh. 25 (1984), 62–71; English transl. in Siberian Math. J. 25 (1984), 735–743] found a trace formula for perturbations of self‐adjoint operators by operators of Hilbert–Schmidt class . Later, Neidhardt introduced a similar formula in the case of pairs of unitaries via multiplicative path in [Math. Nachr. 138 (1988), 7–25].
Arup Chattopadhyay, Soma Das, Chandan Pradhan   +2 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Oscillation Criteria for Sturm–Liouville Dynamic Equations with Deviating Arguments

Mathematics
The aim of this study is to refine the known Riccati transformation technique to provide new oscillation criteria for solutions to second-order dynamic equations over time.
Taher S. Hassan, Clemente Cesarano, Loredana Florentina Iambor, Amir Abdel Menaem, Naveed Iqbal, Akbar Ali   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Iterative oscillation results for second-order differential equations with advanced argument

Electronic Journal of Differential Equations, 2017
This article concerns the oscillation of solutions to a linear second-order differential equation with advanced argument. Sufficient oscillation conditions involving limit inferior are given which essentially improve known results.
Irena Jadlovska
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

On the oscillation of second-order half-linear functional differential equations with mixed neutral term

Journal of Taibah University for Science, 2019
In this article, the authors establish new sufficient conditions for the oscillation of solutions to a class of second-order half-linear functional differential equations with mixed neutral term.
Ercan Tunç, Orhan Özdemir
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source