Results 111 to 120 of about 13,110,779 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Comparison theorems for second-order neutral differential equations of mixed type
Electronic Journal of Differential Equations, 2010 Three comparison theorems are established for the oscillation of the second-order neutral differential equations of mixed type $$ ig(r(t)[x(t)+p_1(t)x(t-sigma_1)+p_2(t)x(t+sigma_2)]'ig)' +q_1(t)x(t-sigma_3) +q_2(t)x(t+sigma_4)=0. $$ Our results are
Tongxing Li
doaj
Notre Dame Journal of Formal Logic, 1992 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Models for Quadratic Algebras Associated with Second Order Superintegrable Systems in 2D
, 2008 There are 13 equivalence classes of 2D second order quantum and classical superintegrable systems with nontrivial potential, each associated with a quadratic algebra of hidden symmetries.
Willard Miller Jr. +5 more
core +1 more source
CZF and Second Order Arithmetic
Annals of Pure and Applied Logic, 2006 CZF + Separation is shown to be equiconsistent with second-order arithmetic, using realizability.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Review of second-order models for adsorption systems
, 2009 [[abstract]]Applications of second-order kinetic models to adsorption systems were reviewed. An overview of second-order kinetic expressions is described in this paper based on the solid adsorption capacity.
Ho, Y.S.
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source