Results 111 to 120 of about 195,148 (324)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Optimality Conditions for Approximate Solutions in Multiobjective Optimization Problems

Journal of Inequalities and Applications, 2010
We study first- and second-order necessary and sufficient optimality conditions for approximate (weakly, properly) efficient solutions of multiobjective optimization problems. Here, tangent cone, -normal cone, cones of feasible directions, second-order
Lee HeungWingJoseph, Gao Ying, Yang Xinmin   +2 more
doaj  

Optimal Control Problem with Necessary Optimality Conditions for the Viscous Dullin-Gottwald-Holm Equation

Abstract and Applied Analysis, 2014
We study the quadratic cost optimal control problems for the viscous Dullin-Gottwald-Holm equation. The main novelty of this paper is to derive the necessary optimality conditions of optimal controls, corresponding to physically meaningful distributive ...
Jinsoo Hwang
doaj   +1 more source

First and second order necessary conditions for stochastic optimal controls [PDF]

, 2016
Hélène Frankowska, Haisen Zhang, Xu Zhang   +2 more
openalex   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Second-order optimality conditions for the bilinear optimal control of a degenerate equation [PDF]

, 2022
Cyrille Kenne, Landry Djomegne, Pascal Zongo   +2 more
openalex   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Legendre–Clebsch Condition for Functional Involving Fractional Derivatives with a General Analytic Kernel

Fractal and Fractional
Fractional calculus of variations for a broad class of fractional operators with a general analytic kernel function is considered. Using techniques from variational analysis, we derive first- and second-order necessary optimality conditions, namely the ...
Faïçal Ndaïrou
doaj   +1 more source

On second order sufficient optimality conditions for a bang-singular arc [PDF]

, 2006
Gianna Stefani, Laura Poggiolini
openalex   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source