Results 101 to 110 of about 20,565,365 (293)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
First-Order and Second-Order Optimality Conditions for Nonsmooth Constrained Problems via Convolution Smoothing [PDF]
, 2010 This paper mainly concerns deriving first-order and second-order necessary (and partly sufficient) optimality conditions for a general class of constrained optimization problems via smoothing regularization procedures based on infimal-like convolutions ...
Eberhard, Andrew C +1 more
core +1 more source
Second-Order Optimality Conditions in Locally Lipschitz Inequality-Constrained Multiobjective Optimization. [PDF]
J Optim Theory Appl, 2020 Constantin E.
europepmc +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Optimality Conditions for Approximate Solutions in Multiobjective Optimization Problems
Journal of Inequalities and Applications, 2010 We study first- and second-order necessary and sufficient optimality conditions for approximate (weakly, properly) efficient solutions of multiobjective optimization problems. Here, tangent cone, -normal cone, cones of feasible directions, second-order
Lee HeungWingJoseph +2 more
doaj
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
Abstract and Applied Analysis, 2014 We study the quadratic cost optimal control problems for the viscous Dullin-Gottwald-Holm equation. The main novelty of this paper is to derive the necessary optimality conditions of optimal controls, corresponding to physically meaningful distributive ...
Jinsoo Hwang
doaj +1 more source
Second-order Karush-Kuhn-Tucker optimality conditions for set-valued optimization
, 2013 In this paper, we propose the concept of a second-order composed contingent derivative for set-valued maps, discuss its relationship to the second-order contingent derivative and investigate some of its special properties.
S. Li (1624891) +2 more
core
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source