Results 91 to 100 of about 20,565,365 (293)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Variational sets and necessary optimality conditions in nonsmooth optimization
Le Matematiche, 1994 In this paper we underline the strict connection between the second-order necessary optimality conditions in nonsmooth optimization and the separation of two particular sets.
Marco Castellani
doaj
Sufficient Efficiency Conditions for Vector Ratio Problem on the Second-Order Jet Bundle
Abstract and Applied Analysis, 2012 Motivated by its possible applications in mechanics and mechanical engineering, in our previous published work (Pitea and Postolache, 2011), we initiated an optimization theory for the second-order jet bundle. We considered the problem of minimization of
Ariana Pitea
doaj +1 more source
KKT reformulation and necessary conditions for optimality in nonsmooth bilevel optimization [PDF]
, 2014 For a long time, the bilevel programming problem has essentially been considered as a special case of mathematical programs with equilibrium constraints (MPECs), in particular when the so-called KKT reformulation is in question.
Zemkoho, Alain B., Dempe, Stephan
core +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
ON SECOND ORDER NECESSARY OPTIMALITY CONDITIONS FOR VECTOR OPTIMIZATION PROBLEMS
Journal of the Korean Mathematical Society, 2003 Summary: Second-order necessary optimality condition for properly efficient solutions of a twice differentiable vector optimization problem is given. We obtain a nonsmooth version of the second-order necessary optimality condition for properly efficient solutions of a nondifferentiable vector optimization problem.
Lee, Gue Myung, Kim, Moon Hee
openaire +2 more sources
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
New bifurcation theorems via the second-order optimality conditions [PDF]
, 2009 We derive new sufficient conditions for bifurcation relying on subtle second-order necessary optimality conditions for abnormal equality-constrained optimization problems.
Arutyunov, A.V. +2 more
core +1 more source