Results 91 to 100 of about 195,148 (324)
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Boundary value problems for systems of second-order functional differential equations
Electronic Journal of Qualitative Theory of Differential Equations, 2000 Systems of second-order functional differential equations $(x'(t)+L(x)(t))'=F(x)(t)$ together with nonlinear functional boundary conditions are considered. Here $L:C^1([0,T];\mathbb{R}^n) \rightarrow C^0([0,T];\mathbb{R}^n)$ and $F:C^1([0,T];\mathbb{R}^n)
S. Stanek
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Second order optimality conditions in nonsmooth unconstrained optimization
, 1998 Summary: Second order necessary and sufficient conditions are given for a nonsmooth function \(f\) defined in a Banach space to attain a minimum at a point in the interior of its domain. At the beginning sufficient conditions in terms of Riemann type derivatives are introduced.
IVANOV, IVAN GINCHEV, GUERRAGGIO, ANGELO
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Second-order optimality conditions in nonsmooth vector optimization
Control and Cybernetics, 2023 Abstract In this paper, we introduce new classes of nonsmooth second-order cone-convex functions and respective generalizations in terms of first and second-order directional derivative. These classes encapsulate several already existing classes of cone-convex functions and their weaker variants.
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
C 1,1 functions and optimality conditions [PDF]
In this work we provide a characterization of C 1,1 functions on Rn (that is, differentiable with locally Lipschitz partial derivatives) by means of second directional divided differences.
La Torre Davide, Rocca Matteo
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Sufficient Efficiency Conditions for Vector Ratio Problem on the Second-Order Jet Bundle
Abstract and Applied Analysis, 2012 Motivated by its possible applications in mechanics and mechanical engineering, in our previous published work (Pitea and Postolache, 2011), we initiated an optimization theory for the second-order jet bundle. We considered the problem of minimization of
Ariana Pitea
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