Results 31 to 40 of about 10,869 (265)
On generalized derivatives for C1,1 vector optimization problems
Journal of Applied Mathematics, 2003 We introduce generalized definitions of Peano and Riemann directional derivatives in order to obtain second-order optimality conditions for vector optimization problems involving C1,1 data.
Davide La Torre
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Trends in Computational and Applied Mathematics, 2019 First and second order necessary optimality conditions of Karush-Kuhn-Tucker type are established for continuous-time optimization problems with equality and inequality constraints.
Moisés Rodrigues Cirilo Monte +1 more
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On a Class of Isoperimetric Constrained Controlled Optimization Problems
Axioms, 2021 In this paper, we investigate the Lagrange dynamics generated by a class of isoperimetric constrained controlled optimization problems involving second-order partial derivatives and boundary conditions.
Savin Treanţă
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
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On a Conjecture in Second-Order Optimality Conditions [PDF]
Journal of Optimization Theory and Applications, 2018 In this paper we deal with optimality conditions that can be verified by a nonlinear optimization algorithm, where only a single Lagrange multiplier is avaliable. In particular, we deal with a conjecture formulated in [R. Andreani, J.M. Martinez, M.L.
Roger Behling +3 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
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Optimality Conditions for the Second-Order Semilinear Differential Inclusions of the Bolza Problem
Journal of Mathematical Sciences and ModellingIn this paper, optimality conditions for the Bolza problem with second-order semilinear differential inclusions (SDFIs) and initial conditions are derived.
Gülseren Çiçek +1 more
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Second-order lower radial tangent derivatives and applications to set-valued optimization
Journal of Inequalities and Applications, 2017 We introduce the concepts of second-order radial composed tangent derivative, second-order radial tangent derivative, second-order lower radial composed tangent derivative, and second-order lower radial tangent derivative for set-valued maps by means of ...
Bihang Xu, Zhenhua Peng, Yihong Xu
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
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