Results 51 to 60 of about 195,148 (324)
On a Class of Isoperimetric Constrained Controlled Optimization Problems
Axioms, 2021 In this paper, we investigate the Lagrange dynamics generated by a class of isoperimetric constrained controlled optimization problems involving second-order partial derivatives and boundary conditions.
Savin Treanţă
doaj +1 more source
Optimal control of an Allen-Cahn equation with singular potentials and dynamic boundary condition
, 2014 In this paper, we investigate optimal control problems for Allen-Cahn equations with singular nonlinearities and a dynamic boundary condition involving singular nonlinearities and the Laplace-Beltrami operator.
Colli, Pierluigi, Sprekels, Jürgen
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Optimality Conditions for the Second-Order Semilinear Differential Inclusions of the Bolza Problem
Journal of Mathematical Sciences and ModellingIn this paper, optimality conditions for the Bolza problem with second-order semilinear differential inclusions (SDFIs) and initial conditions are derived.
Gülseren Çiçek +1 more
doaj +1 more source
Second-order lower radial tangent derivatives and applications to set-valued optimization
Journal of Inequalities and Applications, 2017 We introduce the concepts of second-order radial composed tangent derivative, second-order radial tangent derivative, second-order lower radial composed tangent derivative, and second-order lower radial tangent derivative for set-valued maps by means of ...
Bihang Xu, Zhenhua Peng, Yihong Xu
doaj +1 more source
On strong second-order optimality conditions under relaxed constant rank constraint qualification [PDF]
, 2022 Ademir A. Ribeiro, Mael Sachine
openalex +1 more source
On the Minimization of Convex Functionals of Probability Distributions Under Band Constraints
, 2018 The problem of minimizing convex functionals of probability distributions is solved under the assumption that the density of every distribution is bounded from above and below.
Fauss, Michael, Zoubir, Abdelhak M.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Second-Order Subdifferential Optimality Conditions in Nonsmooth Optimization
SIAM Journal on OptimizationThe paper is devoted to deriving novel second-order necessary and sufficient optimality conditions for local minimizers in rather general classes of nonsmooth unconstrained and constrained optimization problems in finite-dimensional spaces. The established conditions are expressed in terms of second-order subdifferentials of lower semicontinuous ...
Khanh, P. D. +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source