Results 31 to 40 of about 11,355 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On generalized derivatives for C1,1 vector optimization problems
Journal of Applied Mathematics, 2003 We introduce generalized definitions of Peano and Riemann directional derivatives in order to obtain second-order optimality conditions for vector optimization problems involving C1,1 data.
Davide La Torre
doaj +1 more source
Trends in Computational and Applied Mathematics, 2019 First and second order necessary optimality conditions of Karush-Kuhn-Tucker type are established for continuous-time optimization problems with equality and inequality constraints.
Moisés Rodrigues Cirilo Monte +1 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
On a Class of Isoperimetric Constrained Controlled Optimization Problems
Axioms, 2021 In this paper, we investigate the Lagrange dynamics generated by a class of isoperimetric constrained controlled optimization problems involving second-order partial derivatives and boundary conditions.
Savin Treanţă
doaj +1 more source
Second-Order Subdifferential Optimality Conditions in Nonsmooth Optimization
SIAM Journal on OptimizationThe paper is devoted to deriving novel second-order necessary and sufficient optimality conditions for local minimizers in rather general classes of nonsmooth unconstrained and constrained optimization problems in finite-dimensional spaces. The established conditions are expressed in terms of second-order subdifferentials of lower semicontinuous ...
Pham Duy Khanh +3 more
openaire +3 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Optimality Conditions for the Second-Order Semilinear Differential Inclusions of the Bolza Problem
Journal of Mathematical Sciences and ModellingIn this paper, optimality conditions for the Bolza problem with second-order semilinear differential inclusions (SDFIs) and initial conditions are derived.
Gülseren Çiçek +1 more
doaj +1 more source