Results 41 to 50 of about 11,355 (263)
Second-order lower radial tangent derivatives and applications to set-valued optimization
Journal of Inequalities and Applications, 2017 We introduce the concepts of second-order radial composed tangent derivative, second-order radial tangent derivative, second-order lower radial composed tangent derivative, and second-order lower radial tangent derivative for set-valued maps by means of ...
Bihang Xu, Zhenhua Peng, Yihong Xu
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
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AxiomsIn this paper, we study the optimality conditions and perform a stability analysis for the second-order cone constrained variational inequalities (SOCCVI) problem.
Li Wang +4 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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On a Class of Second-Order PDE&PDI Constrained Robust Modified Optimization Problems
Mathematics, 2021 In this paper, by using scalar multiple integral cost functionals and the notion of convexity associated with a multiple integral functional driven by an uncertain multi-time controlled second-order Lagrangian, we develop a new mathematical framework on ...
Savin Treanţă
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Optimal Control through Leadership of the Cucker and Smale Flocking Model with Time Delays
Complexity, 2021 The Cucker and Smale model is a well-known flocking model that describes the emergence of flocks based on alignment. The first part focuses on investigating this model, including the effect of time delay and the presence of a leader.
Adsadang Himakalasa, Suttida Wongkaew
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
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