Results 41 to 50 of about 20,565,365 (293)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Second Order Necessary and Sufficient Optimality Conditions under Abstract Constraints [PDF]
, 1996 Projet PROMATHIn this paper we discuss second order optimality conditions in optimization problems subject to abstract constraints. Our analysis is based on various concepts of second order tangent sets and parametric duality.
Shapiro, Alexander +2 more
core +3 more sources
A Comparison of Second-Order Epiderivatives: Calculus and Optimality Conditions [PDF]
, 1995 The first-order theory of generalized derivatives is now well developed. Significant progress toward a second-order theory has also been made. Two types of second-order directional derivatives appear to be particularly promising for applications to ...
Ward, D.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Optimality Conditions for the Second-Order Semilinear Differential Inclusions of the Bolza Problem
Journal of Mathematical Sciences and ModellingIn this paper, optimality conditions for the Bolza problem with second-order semilinear differential inclusions (SDFIs) and initial conditions are derived.
Gülseren Çiçek +1 more
doaj +1 more source
On a Class of Isoperimetric Constrained Controlled Optimization Problems
Axioms, 2021 In this paper, we investigate the Lagrange dynamics generated by a class of isoperimetric constrained controlled optimization problems involving second-order partial derivatives and boundary conditions.
Savin Treanţă
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
AxiomsIn this paper, we study the optimality conditions and perform a stability analysis for the second-order cone constrained variational inequalities (SOCCVI) problem.
Li Wang +4 more
doaj +1 more source
Second-order lower radial tangent derivatives and applications to set-valued optimization
Journal of Inequalities and Applications, 2017 We introduce the concepts of second-order radial composed tangent derivative, second-order radial tangent derivative, second-order lower radial composed tangent derivative, and second-order lower radial tangent derivative for set-valued maps by means of ...
Bihang Xu, Zhenhua Peng, Yihong Xu
doaj +1 more source