Results 61 to 70 of about 195,148 (324)

Optimality Conditions and Stability Analysis for the Second-Order Cone Constrained Variational Inequalities

Axioms
In this paper, we study the optimality conditions and perform a stability analysis for the second-order cone constrained variational inequalities (SOCCVI) problem.
Li Wang, Yining Sun, Juhe Sun, Yanhong Yuan, Bin Wang   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

On a Class of Second-Order PDE&PDI Constrained Robust Modified Optimization Problems

Mathematics, 2021
In this paper, by using scalar multiple integral cost functionals and the notion of convexity associated with a multiple integral functional driven by an uncertain multi-time controlled second-order Lagrangian, we develop a new mathematical framework on ...
Savin Treanţă
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Optimal Control through Leadership of the Cucker and Smale Flocking Model with Time Delays

Complexity, 2021
The Cucker and Smale model is a well-known flocking model that describes the emergence of flocks based on alignment. The first part focuses on investigating this model, including the effect of time delay and the presence of a leader.
Adsadang Himakalasa, Suttida Wongkaew
doaj   +1 more source

Second-order efficient optimality conditions for set-valued vector optimization in terms of asymptotic contingent epiderivatives [PDF]

, 2021
Nguyễn Minh Tùng
openalex   +1 more source

Optimal Control of Infinite Dimensional Bilinear Systems: Application to the Heat and Wave Equations [PDF]

, 2018
International audienceIn this paper we consider second order optimality conditions for a bilinear optimal control problem governed by a strongly continuous semigroup operator, the control entering linearly in the cost function. We derive first and second
Aronna, Maria Soledad, Bonnans, Joseph Fréderic, Kröner, Axel   +2 more
core   +1 more source

Higher Order Conditions in Nonlinear Optimal Control

, 2011
The most widely used tool for the solution of optimal control problems is the Pontryagin Maximum Principle. But the Maximum Principle is, in general, only a necessary condition for optimality. It is therefore desirable to have supplementary conditions,
Gavriel, Christos, Gavriel, Christos
core   +1 more source