Results 111 to 120 of about 2,352,988 (278)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
A Revenge In Olivier Megaton’s Colombiana Movie (2011): A Psychoanalytic Approach [PDF]
, 2013 This research investigates how the revenge influences the major character’s personality development in Olivier Megaton, viewed for an individual psychological approach, especially behaviorist perspective. Therefore, the study analyzes the movie in terms
, Drs. Abdillah Nugroho, M.Hum. +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Reading out bodily cues to predict interactions
Scientific ReportsSuccessful motor coordination in social interactions requires the rapid interpretation of others’ intentions from their actions. Previous research suggests that individuals use early bodily cues, such as movement kinematics and gaze, to predict others ...
Edoardo Arcuri +2 more
doaj +1 more source
New House, New Furniture, New Room: Children’s Pandemic Landscapes of Care in Chile
Urban PlanningStanding at the intersection between geographies of care and children’s geographies, we present three ethnographic stories (emerging from three ethnographic studies) through which we argue that, as a result of pandemic confinement in Chile, children’s ...
Susana Cortés-Morales +3 more
doaj +1 more source
Epistemic Concerns in the Second-Person Perspective for the Moral Responsibility
Journal of Modern and Contemporary Philosophy, 2021 The conditions under which an agent can be considered morally responsible for her actions raise epistemic concerns like, for instance, whether an agent needs to know what she is doing, and if she must know the moral meaning of what she’s doing to be hold responsible.
openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
You and I, Past and Present. Cognitive Processing of Perspective
Diegesis: Interdisziplinäres E-Journal für Erzählforschung, 2016 This article describes an experiment investigating the relationship between deictic elements of focalisation and readers’ perspective-taking within imaginative conceptualisations of a fictional narrative scene. The text variables tested here are whether
Andrea Macrae
doaj