Results 111 to 120 of about 2,365,205 (295)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Epistemic Concerns in the Second-Person Perspective for the Moral Responsibility

Journal of Modern and Contemporary Philosophy, 2021
The conditions under which an agent can be considered morally responsible for her actions raise epistemic concerns like, for instance, whether an agent needs to know what she is doing, and if she must know the moral meaning of what she’s doing to be hold responsible.
openaire   +1 more source

"The Place of Cultural Explanations and Historical Specificity in Discussions of Modes of Incorporation and Segmented Assimilation" [PDF]

This paper serves as an opportunity to pull together some thoughts and questions about modes of incorporation as an explanation for ethnic differences in behavior.
Joel Perlmann
core  

GOD’S LOVE IN EMILY DICKINSON’S “GOD GAVE A LOAF TO EVERY BIRD” [PDF]

, 2017
This study examines Emily Dickinson\u27s “God Gave a Loaf to Every Bird”, which talks about love, life, and happiness. The purpose of this study is to find out God\u27s love in the poem.
Nuurrochman, Achmad Ghaniy
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Reading out bodily cues to predict interactions

Scientific Reports
Successful motor coordination in social interactions requires the rapid interpretation of others’ intentions from their actions. Previous research suggests that individuals use early bodily cues, such as movement kinematics and gaze, to predict others ...
Edoardo Arcuri, Martina Ardizzi, Vittorio Gallese   +2 more
doaj   +1 more source

New House, New Furniture, New Room: Children’s Pandemic Landscapes of Care in Chile

Urban Planning
Standing at the intersection between geographies of care and children’s geographies, we present three ethnographic stories (emerging from three ethnographic studies) through which we argue that, as a result of pandemic confinement in Chile, children’s ...
Susana Cortés-Morales, Inés Figueroa, Ana Vergara del Solar, Paola Jirón   +3 more
doaj   +1 more source

Perspective Reasoning and the Solution to the Sleeping Beauty Problem [PDF]

, 2018
This paper proposes a new explanation for the paradoxes related to anthropic reasoning. Solutions to the Sleeping Beauty Problem and the Doomsday argument are discussed in detail.
Gao, Xianda
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source