Results 51 to 60 of about 6,758,245 (204)
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment
Annals of Neurology, EarlyView.Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring +18 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo +23 more
wiley +1 more source
Autism Research, EarlyView.ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely ...
Daniela L. Seczon +6 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Eco‐labels and sustainability rating scales are widely used to communicate product sustainability, yet it remains unclear whether combining these signals enhances or undermines consumer responses. Drawing on signaling theory, this study examines how eco‐label familiarity and the presence of a sustainability rating scale jointly shape consumer ...
Sara Raubvogel +3 more
wiley +1 more source
Data and software for the GLM-AED simulation and model calibration of the Falling Creek Reservoir
<p>Revised release of GLM-AED simulation of FCR, applied within the PEST-IES calibration and uncertainty analysis framework</p ...
de Sousa, Eduardo +5 more
core +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Using Global Entrepreneurship Monitor (GEM) 2024 data for Italy and the United Kingdom, this study examines how gender gaps in entrepreneurial perceptions, measured as perceived entrepreneurial skills and fear of failure, vary across age and education within contrasting institutional regimes.
Giusy Sica +4 more
wiley +1 more source
Environmental Policy and Governance, EarlyView.ABSTRACT The international conservation and natural resources communities have increasingly embraced the principle of community participation. This rhetoric around participation has gained power and influence in setting countries' agendas for natural resources governance, largely without a sound understanding of public opinion on the issues.
Rachel S. Friedman +3 more
wiley +1 more source
Polynomial formulation of second derivative multistep methods
, 1982 Following the work of Enright [3] there has been interest in studying second derivative methods for solving stiff ordinary differential equations. Successful implementations of second derivative methods have been reported by Enright [3], Sacks-Davis [9],
S. Kovvali, G. K. Gupta
core +1 more source
The Role of Trade Unions in Environmental Governance: Exploring Workers Legitimacy Judgments
Environmental Policy and Governance, EarlyView.ABSTRACT Trade unions are increasingly expected to play a role in sustainability transitions, but their legitimacy as environmental governance actors remains underexplored. Our study uses a multidimensional framework to examine how workers, both union members and non‐members, evaluate trade union legitimacy “from below.” This framework distinguishes ...
Urša Golob +2 more
wiley +1 more source