Results 61 to 70 of about 6,758,245 (204)

Improved Second Derivative Test for Relative Extrema

, 2007
In this note, a modified Second Derivative Test is introduced for the relative extrema of a single variable function. This improved test overcomes the difficulty of the second derivative vanishing at the critical point, while in contrast the traditional ...
Wu, Yan
core   +1 more source

Individual‐specific resting‐state networks predict language dominance in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to reliably estimate individual‐specific resting‐state cortical networks and determine whether language network topography can predict task‐based language dominance in drug‐resistant epilepsy. Methods We utilized a multisession hierarchical Bayesian model (MS‐HBM) trained on drug‐resistant epilepsy patients ...
Mervyn Jun Rui Lim, Shaoshi Zhang, Shreya Pande, Aihuiping Xue, Ru Kong, Kareem Zaghloul, Sara Inati, B. T. Thomas Yeo   +7 more
wiley   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Introducing the D‐DAND scale: Development of a comprehensive caregiver‐administered tool for Dravet syndrome comorbidities

Epilepsia, EarlyView.
Graphical overview of the Dravet Disease–Associated Neuropsychiatric Disorders (D‐DAND) scale. The D‐DAND scale provides a caregiver‐based, comprehensive assessment of developmental and behavioral comorbidities in Dravet syndrome across six domains: motor abilities, language and social interaction, autonomies, academic skills, emotional/behavioral ...
Bernardo Dalla Bernardina, Francesca Offredi, Alessio Toraldo, Lisa Ouss, Delphine Breuillard, Mathilde Cozzo, Tommaso Lo Barco, Isabella Brambilla, Francesca Darra, Rima Nabbout   +9 more
wiley   +1 more source

Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA‐epilepsy study

Epilepsia Open, EarlyView.
Abstract Objectives Temporal lobe epilepsy (TLE) impacts multiple brain networks. Aberrant functional connectivity has been demonstrated in resting‐state networks (RSNs) that mediate higher brain functions in TLE. This study aimed to identify the reproducible patterns of altered functional connectivity in TLE in a large, international cohort through ...
Victoria Ives‐Deliperi, Jonathan Ipser, James T. Butler, Heath Pardoe, Hamid Soltanian‐Zadeh, Christian Rummel, Roland Wiest, Simon S. Keller, Barbara A. K. Kreilkamp, Anna Elisabetta Vaudano, Alice Ballerini, Stefano Meletti, Gerard Hall, Peter Taylor, Luis Concha, Alfonso Fajardo‐Valdez, Raphael Fernandes Casseb, Fernando Cendes, Clarissa L. Yasuda, Louis Lemieux, John S. Duncan, Esmaeil Davoodi‐Bodj, Orrin Devinsky, Sophia I. Thomopoulos, Dan J. Stein, Paul M. Thompson, Sanjay M. Sisodiya, Taha Gholipour, Carrie R. McDonald   +28 more
wiley   +1 more source

Optimization of moisture content and application rate of hay preservative during high‐moisture alfalfa hay baling in northwestern China

Grassland Research, EarlyView.
Abstract Background Leaf shatter during low‐moisture baling and mold proliferation under high‐moisture conditions pose major challenges in alfalfa hay production. A proprietary propionic acid‐based hay preservative product, LZP, effectively inhibits microbial reproduction in high‐moisture alfalfa bales; however, its optimal moisture thresholds and ...
Zulin Yuan, Fuhou Li, Jing Li, Dongmei Xu, Samaila Usman, Xusheng Guo, Yingwen Yu   +6 more
wiley   +1 more source

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source

Harnessing the Potential of LLMs in Hospital Management: Insights Into Medical Data Inquiry

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Considering the rapid expansion of hospital operations and the increasing digitisation of medical data, there is a pressing need for efficient and intelligent methods to process and analyse large‐scale medical data. Methods We integrated the QLoRA algorithm with ChatGLM2‐6b, Llama2‐7b, and Llama2‐13b models, fine‐tuning them on a ...
Jiaxi Li, Yu Zhang, Jing Zhao, Shengyang He, Danni Li   +4 more
wiley   +1 more source

A Two‐Step Procedure for Generating Domestic and Asymmetric Trade Costs When Data Are Scarce

International Journal of Finance &Economics, EarlyView.
ABSTRACT The practice of domestic trade cost measurement faces several challenges related to data quality, methodology and theory; but the major issue is that of data scarcity. Due to these facts, both domestic and asymmetric trade costs have been ignored despite being a feature of modern trade models.
Arman Mazhikeyev
wiley   +1 more source

Temperature and heat‐load exposure effects on preterm births: Insights from a population‐based study using distributed lag non‐linear models

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Preterm birth presents a substantial health, psychological, and economic burden worldwide. Environmental factors, including temperature fluctuations, are known to influence the risk of preterm birth. This study aimed to investigate the association between high temperatures and heat load and preterm births. Methods Using a time‐series
Bernard Barzilay, Ibrahim Abu‐Kishk, Haim Bibi, Dan Waisman, Sharon Daniel   +4 more
wiley   +1 more source