Results 41 to 50 of about 421,004 (299)

Through change and tradition : the rise of Thebes during the Second Intermediate Period [PDF]

, 2011
This article attempts a historical, archaeological and social analysis of the rule of Thebes at the end of the Second Intermediate Period, through the diachronic survey of the funerary culture. At the end of the Middle Kingdom, the northern tradition
MINIACI, GIANLUCA
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Prediction and validation of short-to-long-term earthquake probabilities in inland Japan using the hierarchical space–time ETAS and space–time Poisson process models

Earth, Planets and Space, 2022
A hierarchical space–time version of the epidemic-type aftershock sequence (HIST–ETAS) model was constructed for an optimally adapted fit to diverse seismicity features characterized by anisotropic clustering as well as regionally distinct parameters ...
Yosihiko Ogata
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The importance of various species of molluscs – second intermediate hosts – in maintaining the circulation of polychostal species of trematodes in the water bodies of the Ukrainian Polissya

Біологічні студії
Background. The paper considers the importance of various species of molluscs as second intermediate hosts in the circulation of polyhostal species of trematodes in the Ukrainian Polissya.
Olena Zhytova
doaj   +1 more source

Risk of disability pension in first and second generation immigrants: the role of age and region of birth in a prospective population-based study from Sweden

BMC Public Health, 2017
Background In several countries, immigrants have higher disability pension (DP) rates than natives. Reasons for this are poorly understood. The aim of this study was to investigate if the risk of diagnosis-specific DP differed in first, second, and ...
D. Di Thiene, M. Helgesson, K. Alexanderson, G. La Torre, J. Tiihonen, E. Mittendorfer-Rutz   +5 more
doaj   +1 more source

Redefining the Hyksos: Immigration and Identity Negotiation in the Second Intermediate Period [PDF]

, 2020
This project reconceptualizes how we conceive of Hyksos identity, primarily through the application of several recent theoretical approaches linked to identity negotiation in contexts of immigration and cultural contact.
Candelora, Danielle
core  

The Hyksos Ruler Khyan and the Early Second Intermediate Period in Egypt: Problems and Priorities of Current Research [PDF]

, 2018
Recent results from the most important sites of the Late Middle Kingdom and the Second Intermediate Period (Edfu, Tell el-Dab'a and Abydos) have broadened our knowledge of the situation in Egypt enormously.

core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source