Results 61 to 70 of about 421,004 (299)

The Israelites in Egypt : an archaeological outlook on the biblical Exodus tradition [PDF]

open access: yes, 2011
During the past few decades the reliability of historical texts, especially the Bible, has been questioned by scholars and archaeologists. This paper analyzes indirect archaeological and historical evidence from Egypt and Syro-Palestine in an attempt to ...
Bless, Jonathon D.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Genotyping and evaluation of antimicrobial susceptibility of Enterococcus species from Turkey

open access: yesJournal of Infection in Developing Countries, 2007
Background: The aim of this study was to investigate the changes with respect to antibacterial resistance and genotype of Enterococcus species isolated in a university hospital during two periods five years apart.Methodology: 321 strains of Enterococcus ...
Yasemin Ersoy,1 Riza Durmaz,2 Mehmet Firat,1 Zeynep Cizmeci,2 and Baris Otlu2
doaj  

The Minoan Thera eruption predates Pharaoh Ahmose: Radiocarbon dating of Egyptian 17th to early 18th Dynasty museum objects.

open access: yesPLoS ONE
The huge volcanic eruption at Thera (Santorini), situated in the Aegean Sea, occurred within the Late Minoan IA archaeological period. However, its temporal association with Egyptian history has long been a controversial subject.
Hendrik J Bruins   +1 more
doaj   +1 more source

Education and second birth rates in Denmark 1981-1994 [PDF]

open access: yes
A high educational attainment is shown to have a positive effect on second birth rates for Danish one-child mothers during the period 1981-94. We examine whether a time-squeeze is a possible explanation: due to the longer enrolment in the educational ...
Mette Gerster   +3 more
core  

Rise of the Hyksos: Egypt and the Levant from the Middle Kingdom to the early Second Intermediate Period [PDF]

open access: yes, 2016
The Second Intermediate Period of Egypt is characterised by the destabilisation of the Egyptian state. It is recognised as the time in which the ḥḳ3.w ḫ3s.wt ‘rulers of foreign lands’, or ‘Hyksos’, extended their control over Egypt during the Fifteenth ...
Anna-Latifa Mourad (12311921)
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Model Thermohaline Trends in the Mediterranean Sea during the Last Years: A Change with Respect to the Last Decades?

open access: yesThe Scientific World Journal, 2012
Temperature and salinity outputs from ECCO (years 93–09) and GLORYS (years 03–09) models have been used to compute the thermohaline and steric sea level trends in the surface (0–150 m), intermediate (150 m–600 m), and deep (600 m–bottom) layers of the ...
F. Javier Soto-Navarro   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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