Results 51 to 60 of about 1,711,443 (299)

The importance of various species of molluscs – second intermediate hosts – in maintaining the circulation of polychostal species of trematodes in the water bodies of the Ukrainian Polissya

Біологічні студії
Background. The paper considers the importance of various species of molluscs as second intermediate hosts in the circulation of polyhostal species of trematodes in the Ukrainian Polissya.
Olena Zhytova
doaj   +1 more source

Risk of disability pension in first and second generation immigrants: the role of age and region of birth in a prospective population-based study from Sweden

BMC Public Health, 2017
Background In several countries, immigrants have higher disability pension (DP) rates than natives. Reasons for this are poorly understood. The aim of this study was to investigate if the risk of diagnosis-specific DP differed in first, second, and ...
D. Di Thiene, M. Helgesson, K. Alexanderson, G. La Torre, J. Tiihonen, E. Mittendorfer-Rutz   +5 more
doaj   +1 more source

Intermediate weight changes and follow-up of dietetic treatment in primary health care: an observational study

BMC Nutrition, 2020
Background Primary health care data have shown that most patients who were treated for overweight or obesity by a dietitian did not accomplish the recommended treatment period.
Lisa D. M. Verberne, Chantal J. Leemrijse, Markus M. J. Nielen, Roland D. Friele   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Overweight and Obesity Among Children and Adolescents in Baladrouz City

Diyala Journal of Medicine, 2019
Background:Obesity in children and adolescents is one of the most serious public health challenges of the 21st century because of the effects of future morbidity.
Wathiq Hassan Farman, Hameed M Majeed
doaj   +2 more sources

Status and trend of tree growth and mortality rate at the CONECOFOR plots, 1997-2004

Annals of Silvicultural Research, 2013
The circumference of trees in the CONECOFOR permanent monitoring plots (PMPs) were measured by three surveys carried out in 1997, 2000 and 2005. Plots were arranged into forest types according to tree species, management system and stand structure: beech
Gianfranco Fabbio, Giada Bertini, Marco Calderisi, Marco Ferretti   +3 more
doaj   +1 more source