Results 1 to 10 of about 3,290,131 (166)

Pediatric immune thrombocytopenia: a focus on eltrombopag as second-line therapy

Hematology, 2023
Background Immune thrombocytopenia (ITP) is the most common acquired bleeding disorder. In both children and adults, the primary goal of any therapeutic approach consists of cessation of bleeding and its prevention.
Giuseppe Palumbo, Piero Farruggia, Ugo Ramenghi, Giovanna Russo, Alessandra Borchiellini, Marco Spinelli, Carlo Dufour, Fiorina Giona, Saverio Ladogana, Marco Zecca, Silverio Perrotta, Andrea Pession, Paola Giordano   +12 more
doaj   +1 more source

Temperature Field of Concrete-Filled Steel Tubular Arch Bridges and Its Application

Advances in Civil Engineering, 2022
This study aimed to reveal the evolution rule and influence mechanism of temperature field and its effect of long-span concrete-filled steel tubular arch bridges in a plateau area.
Qian Zhou, Pengcheng Feng, Jian-Ting Zhou, Shihong Jing, Guohui Zheng, Wuzhao Zhou   +5 more
doaj   +1 more source

Second phase transition line [PDF]

Mathematische Annalen, 2017
We study the phase transion line of the almost Mathieu operator, that separates arithmetic regions corresponding to singular continuous and a.e. pure point regimes, and prove that both purely singular continuous and a.e. pure point spectrum occur for dense sets of frequencies.
Avila, Artur, Jitomirskaya, Svetlana, Zhou, Qi   +2 more
openaire   +2 more sources

Real-World Outcomes of Stage IV NSCLC with PD-L1 ≥ 50% Treated with First-Line Pembrolizumab: Uptake of Second-Line Systemic Therapy

Current Oncology, 2023
Introduction: Platinum-based chemotherapy was compared to single-agent pembrolizumab in advanced non-small cell lung cancer (NSCLC) with PDL1 > 50% in KEYNOTE-024.
Rebekah Rittberg, Bonnie Leung, Aria Shokoohi, Alexandra Pender, Selina Wong, Zamzam Al-Hashami, Ying Wang, Cheryl Ho   +7 more
doaj   +1 more source

Trend of antitubercular drug sensitivity test at a multispecialty hospital in Western India - A Retrospective Analysis

Journal of Marine Medical Society, 2020
Context: Tuberculosis (TB) infection is still a major public health burden in India. India accounts for about 25% of the global TB burden. Worldwide India is the country with highest burden of both TB and multidrug-resistant (MDR) TB.
Shishir Jain, Ashish Bahal, H S Sidhu, Muqtadir Malik, Siddharth Singh   +4 more
doaj   +1 more source

Lurbinectedin in small cell lung cancer

Frontiers in Oncology, 2022
Few treatment options are available for patients with small cell lung cancer (SCLC) in progression after a first-line therapy. A novel therapeutic approach is represented by lurbinectedin, a synthetic derivative of trabectedin that works by inhibiting ...
Anna Manzo, Vincenzo Sforza, Guido Carillio, Giuliano Palumbo, Agnese Montanino, Claudia Sandomenico, Raffaele Costanzo, Giovanna Esposito, Francesca Laudato, Edoardo Mercadante, Carmine La Manna, Paolo Muto, Giuseppe Totaro, Rossella De Cecio, Carmine Picone, Maria Carmela Piccirillo, Giacomo Pascarella, Nicola Normanno, Nicola Normanno, Alessandro Morabito   +19 more
doaj   +1 more source

Real‐world outcomes among patients with advanced or metastatic biliary tract cancers initiating second‐line treatment

Cancer Medicine, 2023
Background Limited data are available regarding second‐line (2 L) treatment for advanced or metastatic biliary tract cancers (BTC) in the US real‐world setting.
David P. Cosgrove, Emily S. Reese, Nicole M. Fulcher, Sarah S. Bobiak, Francois‐Xavier Lamy, Arthur Allignol, Marley Boyd, Seyed H. Mahmoudpour   +7 more
doaj   +1 more source

VEGFR Inhibitors for Uterine Metastatic Perivascular Epithelioid Tumors (PEComa) Resistant to mTOR Inhibitors. A Case Report and Review of Literature

Frontiers in Oncology, 2021
Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms. PI3K/AKT/mTOR pathway upregulation is critical for their pathogenesis and is often associated with TSC1/TSC2 inactivation.
Aikaterini Liapi, Patrice Mathevet, Fernanda G. Herrera, Delfyne Hastir, Apostolos Sarivalasis   +4 more
doaj   +1 more source

Current Options for Second-Line Systemic Therapy in Metastatic Renal Cell Carcinoma

Journal of Kidney Cancer and VHL, 2022
Standard systemic therapy of advanced renal cell carcinoma (RCC) involves targeting angiogenesis, mainly through tyrosine kinase inhibitors (TKI) against the vascular endothelial growth factor receptor (VEGFR) pathway and targeting the immune ...
Iraklis C. Mitsogiannis, Maria Mitsogianni, Maria Papathanassiou, Maria Anagnostou, Ioannis Tamposis, Lampros Mitrakas, Maria Samara, Vassilios Tzortzis, Panagiotis J. Vlachostergios   +8 more
doaj   +1 more source

Рembrolizumab as second line therapy for hepatocellular patient

Медицинский совет, 2021
The optimal hepatocellular cancer (HCC) therapy remains a challenge. Due to checkpoint inhibitors patients with intolerance to the targeted therapy and or those with the impaired liver function can get an appropriate drug therapy.
I. A. Dzhanyan, V. V. Breder, O. I. Borisova, K. K. Laktionov   +3 more
doaj   +1 more source