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Regulation of Second Messenger Systems and Intracellular Pathways
2009The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell ...
MERIGHI, Stefania +3 more
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Pharmacology of stomoxytachykinin receptor depends on second messenger system
Peptides, 2005STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned STKR cDNA. Pronounced differences in
Poels, J. +8 more
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Opioid-Coupled Second Messenger Systems
1988Receptors are normally considered as composed of two separate parts: a specific ligand binding site and an effector component that causes a specific biological response subsequent to agonist binding. Historically, neurotransmitter receptors have been identifed by both properties.
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The second messenger system as the morphogenetic field
Biochemical and Biophysical Research Communications, 1989For sixty years morphogenetic fields have been assumed. We suggest a realization for such a field: the second messenger (in particular cyclic AMP) and its substrate (in particular ATP) are suggested to be the activator-morphogen and inhibitor respectively. Gene transcription is derived as an hysteretic function of the second messenger (cyclic AMP).
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Second Messenger Systems and Signal Transduction Mechanisms
1997Hormones are secreted, reach their target, and bind to a receptor. The interaction of the hormone with the receptor produces an initial signal that, through a series of steps, results in the final hormone action. How does the binding of a hormone to a receptor result in a cellular action?
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Second Messenger Systems Underlying Plasticity at the Neuromuscular Junction
International Review of Neurobiology, 1999Publisher Summary The Drosophila neuromuscular junction provides elegant significant experimental model to study signal transduction pathways that mediate synaptic plasticity because of its accessibility to electrophysiological techniques, morphological analyses, and pharmacological and genetic manipulations at identifiable synapses.
F, Hannan, Y, Zhong
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Neurotransmitters and Second Messenger Systems in the Carotid Body
1993It is well known that multiple cellular events are regulated by second messenger systems (Greengard and Costa, 1970; Sekar et al., 1986; Hockberger et al., 1987). Among second messengers, cAMP have been shown to modulate several ionic channels and neurotransmitter synthesis and release in different structures (Joh et al.,1978; Hockberger et al., 1987 ...
M T, Pérez-García +3 more
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NEW TOOLS FOR THE LOCALIZATION OF SECOND MESSENGER SYSTEMS
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Probes available for the localization of components of second messenger systems include G‐protein oligonucleotides which have been used to produce cDNA probes to label G‐protein mRNA by in situ hybridization histochemistry.2. Enzymes involved in second messenger responses have been labelled with [3H]‐forskolin (Gs‐linked adenylate cyclase ...
R J, Summers, L R, McMartin
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Differentiation of second messenger systems in mast cell activation
Agents and Actions, 1989Pretreatment of rat peritoneal mast cells with either Staurosporine or an analog K-252a, lead to a dose-related inhibition of histamine release when stimulated with Anti-IgE (IC50: Staurosporine = 110 nM; K-252a = 100 nM). In contrast, the two PKC inhibitors (1-1000 nM) failed to inhibit histamine release induced by compound 48/80 (0.5-1 micrograms/ml).
J R, White, D, Zembryki
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Second Messenger Systems Involved in Heart Mechanotransduction
2007Mechanical stress can be considered one of the major stimuli that evoke hypertrophic responses including reprogramming of gene expression in cardiac myocytes. Therefore, it is important to understand how mechanical loading is sensed by cardiomyocytes and converted into intracellular biomechanical signals leading to cardiac hypertrophy.
Hiroshi Hasegawa +4 more
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