Results 211 to 220 of about 360,391 (324)

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

S‐adenosyl methionine‐AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity [PDF]

Yongye Huang, Sihui Zhang, Min Wu
openalex   +1 more source

A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4. [PDF]

Biochem J
Orzechowski M, Hoikkala V, Chi H, McMahon S, Gloster T, White MF.   +5 more
europepmc   +1 more source

Impact of changed c-di-AMP levels and hypoosmotic stress on the transcriptome of <i>Haloferax volcanii</i> and on RCK domain-containing proteins. [PDF]

Microlife
Ren H, Braun F, Grünberger F, van der Does C, Grohmann D, Albers SV.   +5 more
europepmc   +1 more source

Earl W. Sutherland's Discovery of Cyclic Adenine Monophosphate and the Second Messenger System

, 2005
Nicole Kresge, Robert Simoni, Robert L. Hill   +2 more
openalex   +1 more source

Transient Focal Ischemia Affects the cAMP Second Messenger System and Coupled Dopamine D₁ and 5-HT_1A Receptors in the Living Monkey Brain: A Positron Emission Tomography Study Using Microdialysis [PDF]

, 2004
Hideo Tsukada, Dai Fukumoto, Shingo Nishiyama, Kengo Sato, Takeharu Kakiuchi   +4 more
openalex   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Acute Pleuropericardial Syndrome Following Messenger Ribonucleic Acid (mRNA) COVID-19 Vaccination: A Case Report. [PDF]

Cureus
Yusuf O, Omotosho A, Moore S, Khan A.
europepmc   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source