Results 101 to 110 of about 13,156,873 (271)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Second-Order Management – How Second-Order Concepts Contribute to Solutions within Complex Environments [PDF]
Journal of Systemics, Cybernetics and Informatics, 2020 In our daily practice as management consultants we observe disorientation, misconceptions, and open questions about the suitability, limitations, and/or benefits of novel management approaches.
Philipp Belcredi +1 more
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2007 Using a class of test functions $Phi(t,s,T)$ defined by Sun [13] and a generalized Riccati technique, we establish some new oscillation criteria for the second-order neutral differential equation with distributed deviating argument $$ (r(t)psi(x(t))Z'(t))
Gaihua Gui, Zhiting Xu
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Second order tangency conditions and differential inclusions: a counterexample and a remedy
Electronic Journal of Differential Equations, 2009 In this paper we show that second order tangency conditions are superfluous not to say useless while discussing the existence condition for certain second order differential inclusions. In this regard, a counterexample is provided even in the simpler
Corneliu Ursescu
doaj
Maximum Inaccuracies of Second Order [PDF]
Computer Science Journal of Moldova, 2015 Let an indirectly measurable variable $Y$ be represented as a function of finite number of directly measurable variables $X_1, \linebreak X_2, ..., X_n$. We introduce maximum absolute and relative inaccuracies of second order of $Y$ -- this idea is a
Kiril Kolikov +3 more
doaj
Spacetime Encodings III - Second Order Killing Tensors
, 2009 This paper explores the Petrov type D, stationary axisymmetric vacuum (SAV) spacetimes that were found by Carter to have separable Hamilton-Jacobi equations, and thus admit a second-order Killing tensor. The derivation of the spacetimes presented in this
Brink, Jeandrew
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2016 We consider the following second order differential equation with delay $$ \begin{cases} \begin{split} (Lx)(t)&\equiv{x''(t)+\sum_{j=1}^p {a_{j}(t)x'(t-\tau_{j}(t))}+\sum_{j=1}^p {b_{j}(t)x(t-\theta_{j}(t))}}=f(t), & t\in[0,\omega] \end{split} \\ x(t_k)=
Alexander Domoshnitsky +2 more
doaj +1 more source