Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Pupils language competence in the primary school literature review [PDF]
This paper, which forms part of an ongoing PhD study, attempts a summary overview of research on pupil competence in modern languages in the primary school, as presented by a Systematic Literature Review (SLR).
Kanaki, Argyro; id_orcid
core
Prevalence of lower second premolar agenesis and study of rhizolysis of primary second molars without permanent successor with 2 methods [PDF]
2025 Acuerdos transformativos CRUEObjectives: The aims of this study were to estimate the prevalence of lower second premolar (2Pr) agenesis and to quantify rhizolysis of the preceding primary molars.
Garcia-Navas Fernández de la Puebla, Maria Lourdes +4 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Familial risks of second primary cancers and mortality in ovarian cancer patients [PDF]
Guoqiao Zheng,1,2 Subhayan Chattopadhyay,1,2 Asta Försti,1,3 Kristina Sundquist,3–6 Kari Hemminki1,3 1Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany; 2Faculty of ...
Sundquist K +4 more
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
International languages in primary schools: Aims, constraints, and one way forward [PDF]
The present policy of the Ministry of Education is that all schools should offer instruction in an additional language from Year 7 to Year 10. The additional languages may be te reo Māori, a Pacific language, or one of several international languages ...
Barnard, Roger
core
Guoqiao Zheng,1– 3 Kristina Sundquist,4– 6 Jan Sundquist,4– 6 Asta Försti,1,4,7,8 Akseli Hemminki,9,10 Kari Hemminki1,2,4,11 1Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg D-69120 ...
Zheng G +5 more
doaj
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Advanced head and neck cancer: Long-term results of chemo-radiotherapy, complications and induction of second malignancies [PDF]
Background: Chemo-radiotherapy is superior to radiotherapy alone in the treatment of advanced, inoperable head and neck cancer. The long-term treatment results, the induction of second malignant tumors, and other long-term toxicities are not well defined.
Schorer, H. +6 more
core +1 more source

