Results 31 to 40 of about 452,511 (266)
Propulsion and Power Research, 2015 The gas turbine engine internal air system provides cooling and sealing air to a series of critical subsystems and components such as high pressure gas turbine blades, as well as controlling the thrust load on the turbine and compressor spool assembly ...
P.R.N. Childs, B. Garvey
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Experimental investigation of solid holdup in twin-cyclone combustor [PDF]
Research & Knowledge, 2016 In this study, the hydrodynamics behaviors and solid holdup in a twin-cyclone combustor with a swirling fl uidized bed were investigated under a wide range of cold–air operating conditions. Silica sand of three different particle size ranges: 600–710 μm,
Kasama Sirisomboon, Nuttachai Kummun
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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Research and Development of Carbon Dioxide Refrigeration Technology [PDF]
E3S Web of Conferences, 2020 With the agreement of the Kigali amendment to the Montreal Protocol, the timetable for the reduction of the mandate and the limitation of 18 controlled substances are being phased in. This has brought great challenges to the transformation, upgrading and
Wang Qi, Li Guangpeng
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Calculation of Labyrinth Seals in the Secondary Air System of Aircraft Engine [PDF]
The Open Mechanical Engineering Journal, 2014 The labyrinth seals perform the important functions in the aircraft engine systems operation, which aim to reduce the air leakages and the mutual system interference reduction. The calculation of the labyrinth seal characteristics is performed simply by using the analytical relationships or the modern tools of numerical analysis.
Andrei Tisarev +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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Some Aerodynamic Aspects of Engine Secondary Air Systems [PDF]
Journal of Engineering for Gas Turbines and Power, 1989 Internal cooling air systems of turbomachines contain various fluid flow components, i.e., rotating holes, tapping configurations, coverplates, labyrinth seals, etc., for which only the basic aerodynamics are known. Numerical calculations for these elements are carried out and compared with test results showing fair agreement in general.
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