Results 41 to 50 of about 2,859,954 (336)

Some Aerodynamic Aspects of Engine Secondary Air Systems [PDF]

Journal of Engineering for Gas Turbines and Power, 1989
Internal cooling air systems of turbomachines contain various fluid flow components, i.e., rotating holes, tapping configurations, coverplates, labyrinth seals, etc., for which only the basic aerodynamics are known. Numerical calculations for these elements are carried out and compared with test results showing fair agreement in general.
openaire   +1 more source

Atmospheric fungal nanoparticle bursts. [PDF]

, 2020
Aerosol nanoparticles play an important role in the climate system by affecting cloud formation and properties, as well as in human health because of their deep reach into lungs and the circulatory system. Determining nanoparticle sources and composition
Draper, Danielle C, Lawler, Michael J, Smith, James N   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Development of the premixing injector in burner system [PDF]

, 2013
The alternative fuel is good attention especially for renewable and prevention energy such as biodiesel. Biodiesel fuel (BDF) has a potential for external combustion. BDF is one of the hydrocarbon fuels.
Sies, Mohamad Farid
core  

Environmental Impact Assessment, on the Operation of Conventional and More Electric Large Commercial Aircraft [PDF]

, 2013
Global aviation is growing exponentially and there is a great emphasis on trajectory optimization to reduce the overall environmental impact caused by aircraft. Many optimization techniques exist and are being studied for this purpose.
Lawson, Craig P., Sabatini, Roberto, Seresinhe, R.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Optimization of secondary air system for enhanced combustion efficiency and CO2 emission reduction in 1000MW boilers

Results in Engineering
The optimization of combustion processes in large-scale power generation systems is crucial for improving energy efficiency and reducing carbon dioxide (CO2) emissions.This study focuses on enhancing the combustion state in a 1000MW double tangential ...
Tianlong Wang, Chaoyang Wang, Huibo Yan, Zhiqiang Liu, Shuai Ma   +4 more
doaj   +1 more source

Biological implications of high-energy cosmic ray induced muon flux in the extragalactic shock model

, 2011
A ~ 62 My periodicity in fossil biodiversity has been observed in independent studies of paleontology databases over ~0.5Gy. The period and phase of this biodiversity cycle coincides with the oscillation of our solar system normal to the galactic disk ...
Adrian L. Melott, Alpen, Arens, Atri, Atri, Bailer-Jones, Chen, Cornette, Cucinotta, Dimitra Atri, Ferrari, Feulner, Gies, Groom, Hebbeker, Karam, Kirkby, Lieberman, McNulty, Medvedev, Melott, Melott, Melott, Melott, Melott, O'Brien, Pelliccioni, Rohde, Simonsen, Usoskin   +29 more
core   +1 more source