Results 61 to 70 of about 2,859,954 (336)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Combined Organic Rankine Cycle-Heat Pump System for Domestic Hot Water Application [PDF]

, 2016
This paper investigates a novel system to improve the efficiency of using natural gas for domestic heating. The exhaust from a gas burner powers a small-scale Organic Rankine Cycle (ORC) system using hexane as the working fluid, which is used to directly
Al-Tameemi, Mohammed, Collings, Peter, Yu, Zhibin   +2 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Wind Tunnel Experiment and Numerical Simulation of Secondary Flow Systems on a Supersonic Wing

Aerospace
Aircraft secondary flow systems are small-flow circulation devices that are used for thermal and cold management, flow control, and energy generation on aircraft. The aerodynamic characteristics of main-flow-based inlets have been widely studied, but the
Sheng Zhang, Zheng Lin, Zeming Gao, Shuai Miao, Jun Li, Lifang Zeng, Dingyi Pan   +6 more
doaj   +1 more source

The PREV'AIR system, an operational system for large scale air quality forecasts over Europe : applications at the local scale [PDF]

, 2004
International audienceSince Summer 2003, the PREV'AIR system has been delivering through the Internet daily air quality forecasts over Europe. This is the visible part of a wider collaborative project - the PREV'AIR project - launched by the French ...
Bessagnet, Bertrand, Colosio, Joëlle, Honore, Cécile, Malherbe, Laure, Meleux, Frédérik, Poisson, Nathalie, Rouil, Laurence, Vautard, Robert   +7 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Development of a measuring system for determining the air density correction factor for ionization chambers open to the atmosphere [PDF]

Nuclear Technology and Radiation Protection
This paper introduces a measuring system designed to determine the air density correction factor for ionization chambers open to the atmosphere. The system is intended for use in clinical and radiotherapy facilities, secondary standard dosimetry
Đaletić Miloš V.
doaj   +1 more source

Design and operating parameters of a fulidized bed for the combustion of municipal solid waste using standpipes air distributors [PDF]

, 2009
Hydrodynamic studies and combustion of simulated and actual municipal solid waste were carried out in a fluidized bed system. A wide range of parameters was investigated in hydrodynamic study after which the optimum parameters were implemented in the ...
Johari, Anwar
core