Results 51 to 60 of about 2,859,954 (336)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Vrishabhavathi Valley Wastewater Treatment Plant System Upgrade [PDF]

open access: yes, 2017
Sixteen activated sludge tanks, eight secondary clarifiers, and four return pump stations were designed for the Vrishabhavathi Wastewater Treatment plant in Bangalore India.
Chellaram, Vijay, Miller, Christian
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Research on a Micro-Grid Frequency Modulation Strategy Based on Optimal Utilization of Air Conditioners

open access: yesEnergies, 2016
With the proportion of air conditioners increasing gradually, they can provide a certain amount of frequency-controlled reserves for a micro-grid. Optimizing utilization of air conditioners and considering load response characteristics and customer ...
Qingzhu Wan, Yuan Bian, Yalan Chen
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Cellulose-binding domains as a tool for paper recycling [PDF]

open access: yes, 2003
Treatment of secondary paper fibres with cellulose-binding domains allows for improvements of pulp drainability and of paper mechanical properties. The interfacial system fibrewater- fibre, and after drying, fibre-air-fibre, may be affected by the CBD ...
Duarte, A. P.   +4 more
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

Analysis and Simulation of Forced Ventilation in Special Condition

open access: yesMATEC Web of Conferences, 2018
The research subject of the current work is heating of the closed area by the forced air ventilation system with heat recovery ventilator and floor radiators. The simulation model was made in ANSYS Fluent 14.0. In the simulation were taken to account the
Rimár Miroslav   +3 more
doaj   +1 more source

Dispatch for Urban Integrated Heat and Power System Considering Secondary PM2.5 Under Smart Environmental Sensing

open access: yesIEEE Access, 2019
To improve the air quality and reduce the human settlement pollution, the effects of initial air pollutant emissions from urban heat and power generation with the diffusion of pollutants were often considered in the energy system dispatch, but the ...
Sicheng Peng   +5 more
doaj   +1 more source

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