Results 31 to 40 of about 14,134,494 (244)

Transient 2D FEM-fluid network coupling for thermo-mechanical whole gas turbine engine simulations: modelling features and applications [PDF]

E3S Web of Conferences, 2020
In order to control the thermo-mechanical stresses that large heavy-duty power generation turbines have to face nowadays in their frequent operational transients, the analysis of the heat transfer between main flow, secondary air systems and structural ...
Giuntini Sabrina, Andreini Antonio, Facchini Bruno, Mantero Marco, Pirotta Marco, Olmes Sven   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessment of cool thermal storage strategies in Kuwait [PDF]

, 2006
The extensive use of air conditioning for indoor cooling in offices and large commercial buildings in Kuwait represents a major part of the power and electricity consumption in that country.
Sebzali, Mohamed
core   +6 more sources

Impact assessment of Controlled Mechanical Ventilation systems for air quality in school buildings: a study protocol

Epidemiology, Biostatistics and Public Health
Background: Indoor air is an important public health issue and the COVID-19 pandemic has highlighted even more the importance of indoor air quality in schools.
Maria Francesca Rossi, Flavia Beccia, Raimondo Leone, Clara Peretti, Luca Verdi, Costanzo Di Perna, Sergio Montelpare, Giuseppina Caggiano, Umberto Moscato, necessARIA Working Group   +9 more
doaj   +1 more source

An Integrated Methodology for Scenarios Analysis of Low Carbon Technologies Uptake towards a Circular Economy: The Case of Orkney

Energies, 2022
This study aims to create a comprehensive, holistic approach to evaluate the environmental, energy, and economic impacts of air source heat pump deployment scenarios through: (i) a life cycle assessment of air source heat pumps in Orkney houses, (ii ...
Selman Sevindik, Catalina Spataru
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Active supply diffuser application in all-air heating systems [PDF]

, 2019
Substantial reductions in energy use can be achieved by promoting low energy building technologies such as all-air systems. There is an idea that integrating active supply diffuser with all-air systems can potentially improve their performance.
Madessa, Habtamu Bayera, Rabani, Mehrdad, Nord, Natasa   +2 more
core   +1 more source

Investigations at a Micro-Scale Installation Regarding Emission Reduction by Air Staging and Integrated Catalysis

Chemical Engineering Transactions, 2014
The use of biomass for heat production in small scale combustion systems provides an on-site energy supply from renewable resources. Low pollutant emissions as well as heat output on demand are the basic requirements for the application of ...
I. Hartmann, M. Koenig, M. Matthes
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source