Results 51 to 60 of about 273,990 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Investigations at a Micro-Scale Installation Regarding Emission Reduction by Air Staging and Integrated Catalysis

open access: yesChemical Engineering Transactions, 2014
The use of biomass for heat production in small scale combustion systems provides an on-site energy supply from renewable resources. Low pollutant emissions as well as heat output on demand are the basic requirements for the application of ...
I. Hartmann, M. Koenig, M. Matthes
doaj   +1 more source

Multi-Objective Optimisation-Based Design of an Electric Vehicle Cabin Heating Control System for Improved Thermal Comfort and Driving Range

open access: yesEnergies, 2021
Modern electric vehicle heating, ventilation, and air-conditioning (HVAC) systems operate in more efficient heat pump mode, thus, improving the driving range under cold ambient conditions.
Ivan Cvok, Igor Ratković, Joško Deur
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Development of a measuring system for determining the air density correction factor for ionization chambers open to the atmosphere [PDF]

open access: yesNuclear Technology and Radiation Protection
This paper introduces a measuring system designed to determine the air density correction factor for ionization chambers open to the atmosphere. The system is intended for use in clinical and radiotherapy facilities, secondary standard dosimetry
Đaletić Miloš V.
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Studies on SI engine simulation and air/fuel ratio control systems design [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.More stringent Euro 6 and LEV III emission standards will immediately begin execution on 2014 and 2015 respectively.
Bai, Yang, Yang Bai
core  

Dispatch for Urban Integrated Heat and Power System Considering Secondary PM2.5 Under Smart Environmental Sensing

open access: yesIEEE Access, 2019
To improve the air quality and reduce the human settlement pollution, the effects of initial air pollutant emissions from urban heat and power generation with the diffusion of pollutants were often considered in the energy system dispatch, but the ...
Sicheng Peng   +5 more
doaj   +1 more source

Impact of low-pressure systems on winter heavy air pollution in the northwest Sichuan Basin, China [PDF]

open access: yesAtmospheric Chemistry and Physics, 2018
The cities of Chengdu, Deyang, and Mianyang in the northwest Sichuan Basin are part of a rapidly developing urban agglomeration adjoining the eastern slopes of the Tibetan Plateau.
G. Ning   +11 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

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