Results 41 to 50 of about 273,928 (312)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessment of cool thermal storage strategies in Kuwait [PDF]

, 2006
The extensive use of air conditioning for indoor cooling in offices and large commercial buildings in Kuwait represents a major part of the power and electricity consumption in that country.
Sebzali, Mohamed
core  

An Integrated Methodology for Scenarios Analysis of Low Carbon Technologies Uptake towards a Circular Economy: The Case of Orkney

Energies, 2022
This study aims to create a comprehensive, holistic approach to evaluate the environmental, energy, and economic impacts of air source heat pump deployment scenarios through: (i) a life cycle assessment of air source heat pumps in Orkney houses, (ii ...
Selman Sevindik, Catalina Spataru
doaj   +1 more source

Some Aerodynamic Aspects of Engine Secondary Air Systems [PDF]

Journal of Engineering for Gas Turbines and Power, 1989
Internal cooling air systems of turbomachines contain various fluid flow components, i.e., rotating holes, tapping configurations, coverplates, labyrinth seals, etc., for which only the basic aerodynamics are known. Numerical calculations for these elements are carried out and compared with test results showing fair agreement in general.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Secondary Surveillance Radar for Air Traffic Control

, 2021
Najvažniji faktor za sigurno održavanje zračne plovidbe je primjena radara u kontroli zračnog prometa. Nadzor zračnog prometa obavlja se korištenjem različitih nadzornih tehnologija, što uključuje radarske sustave (primarni i sekundarni), sustav ...
Micelli, Katarina
core  

Impact assessment of Controlled Mechanical Ventilation systems for air quality in school buildings: a study protocol

Epidemiology, Biostatistics and Public Health
Background: Indoor air is an important public health issue and the COVID-19 pandemic has highlighted even more the importance of indoor air quality in schools.
Maria Francesca Rossi, Flavia Beccia, Raimondo Leone, Clara Peretti, Luca Verdi, Costanzo Di Perna, Sergio Montelpare, Giuseppina Caggiano, Umberto Moscato, necessARIA Working Group   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Investigations at a Micro-Scale Installation Regarding Emission Reduction by Air Staging and Integrated Catalysis

Chemical Engineering Transactions, 2014
The use of biomass for heat production in small scale combustion systems provides an on-site energy supply from renewable resources. Low pollutant emissions as well as heat output on demand are the basic requirements for the application of ...
I. Hartmann, M. Koenig, M. Matthes
doaj   +1 more source

Multi-Objective Optimisation-Based Design of an Electric Vehicle Cabin Heating Control System for Improved Thermal Comfort and Driving Range

Energies, 2021
Modern electric vehicle heating, ventilation, and air-conditioning (HVAC) systems operate in more efficient heat pump mode, thus, improving the driving range under cold ambient conditions.
Ivan Cvok, Igor Ratković, Joško Deur
doaj   +1 more source