Results 91 to 100 of about 7,970,747 (301)

BeQuali – an archive in question

open access: yesRevue d'anthropologie des connaissances, 2016
This paper addresses the difficulties generated by the archiving of data in social sciences and humanities through a case study: the set-up of a French qualitative archive, beQuali, whose first years (2006-2013) happened to be full of frictions.
Sophie Duchesne, Mathieu Brugidou
doaj   +1 more source

Discriminant Analysis and Secondary-Beam Charge Recognition

open access: yes, 2007
The discriminant-analysis method has been applied to optimize the exotic-beam charge recognition in a projectile fragmentation experiment. The experiment was carried out at the GSI using the fragment separator (FRS) to produce and select the relativistic
A. Boudard   +63 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Secondary Analysis of Database-Stored Qualitative Data: QUESSY as Interface Between QDA and RDBMS Systems

open access: yesForum: Qualitative Social Research, 2005
Data bases or relational data base management systems (RDBMS) offer advantages over the common saving as data files for the storage of qualitative data in secondary analysis archives and larger research projects.
Heiner Legewie   +5 more
doaj  

Iterated Differential Forms IV: C-Spectral Sequence

open access: yes, 2006
For the multiple differential algebra of iterated differential forms (see math.DG/0605113 and math.DG/0609287) on a diffiety (O,C) an analogue of C-spectral sequence is constructed.
A. M. Vinogradov   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Ion-induced electron production in tissue-like media and DNA damage mechanisms

open access: yes, 2008
We propose an inclusive approach for calculating characteristics of secondary electrons produced by ions/protons in tissue-like media. This approach is based on an analysis of the projectile's interaction with the medium on the microscopic level.
Greiner, W.   +6 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Phase Decomposition and Chemical Inhomogeneity in Nd2-xCexCuO4

open access: yes, 2004
Extensive X-ray and neutron scattering experiments and additional transmission electron microscopy results reveal the partial decomposition of Nd2-xCexCuO4 (NCCO) in a low-oxygen-fugacity environment such as that typically realized during the annealing ...
A. F. Marshall   +20 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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