Results 51 to 60 of about 27,569,029 (304)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Behavioral SciencesThis meta-analysis synthesized 34 published single-case design studies on functional communication training (FCT) for young children with autism spectrum disorder (ASD).
Kwang-Sun Cho Blair +2 more
doaj +1 more source
Secondary Data Analysis of Epidemiology in Asia
Journal of Epidemiology, 2014 It is widely acknowledged that there is great potential for utilizing databases in health care systems in developed countries.1 Modern health care databases have two characteristics that make them attractive to epidemiologists who work on ‘real-world’ problems: routinely conducted data collection and perpetual electronic data storage.
openaire +4 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Journal für Psychologie, 2007 Qualitative data are a rich and often not fully exploited source of research material. Nonetheless they are seldom reanalysed. The analysis of a nationwide German survey of qualitative researchers shows that there are some concerns and open issues ...
Irena Medjedovic
doaj
Journal of Physical Fitness and Sports Medicine, 2018 This study investigated the association between exercise type and self-rated health (SRH) in Japanese adults. A secondary data analysis was performed on the results of a cross-sectional study of 2,000 Japanese adults (20 years or older) who responded to ...
Zhennan Wang +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in NutritionBackgroundRecent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.ObjectivesOur study aimed to examine the ...
Rong Shuai +4 more
doaj +1 more source
Nursing Open, 2019 Aims To explore the relationship between nurse–nurse collaboration and job satisfaction among hospital nurses and to test and refine a model explaining this relationship. Design A secondary analysis of a cross‐sectional survey. Methods Registered nurses (
Tuija Ylitörmänen +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source