Results 71 to 80 of about 4,004,716 (311)

Implementation of the three good questions—A feasibility study in Dutch hospital departments

Health Expectations, 2019
Objectives To determine the feasibility of pragmatic implementation strategies for three good questions (in Dutch: Drie Goede Vragen; 3GV. What are my options; what are the risks and benefits related to these options; and what does this mean for my ...
Mirjam M. Garvelink, Marja Jillissen, Anouk Knops, Jan A. M. Kremer, Rosella P.M.G. Hermens, Marjan J. Meinders   +5 more
doaj   +1 more source

A feminist political economy analysis of public policies related to care: a thematic review [PDF]

, 2013
Unpaid care work is directly linked to the economic empowerment of women and girls. There is a large and robust body of evidence about the extent of unpaid care work that women and girls do, and its contributions to both the economy and human development
Chopra, Deepta, Iyer, Padmini, Kelbert, Alexandra Wanjiku   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Determinants of hepatitis B vaccination status in health care workers of two secondary care hospitals of Sindh, Pakistan: a cross-sectional study

Human Vaccines & Immunotherapeutics, 2021
Background Health care workers (HCWs) are at high risk of Hepatitis B virus (HBV) transmission. Hepatitis B vaccination is effective in protecting against HBV infection.
Salman Muhammad Soomar, Amna Rehana Siddiqui, Syed Iqbal Azam, Mairaj Shah   +3 more
doaj   +1 more source

Regional data exchange to improve care for veterans after non-VA hospitalization: a randomized controlled trial [PDF]

, 2019
BACKGROUND: Coordination of care, especially after a patient experiences an acute care event, is a challenge for many health systems. Event notification is a form of health information exchange (HIE) which has the potential to support care ...
Bean, Andrew M., Boockvar, Kenneth S., Dixon, Brian E., Guerrero, Vivian M., Koufacos, Nicholas S., May, Justine, Penrod, Joan D., Schubert, Cathy C., Schwartzkopf, Ashley L.   +8 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

What proportion of adult allergy referrals to secondary care could be dealt with in primary care by a GP with special interest? [PDF]

, 2016
Background: The concept of a General Practitioner with Special Interest (GPwSI) was first proposed in the 2000 National Health Service Plan, as a way of providing specialised treatment closer to the patient’s home and reducing hospital waiting times ...
A Bowling, DP Kernick, H Smith, J Coast, J Powell, JR Landis, ML Levy, R Gilbert, Y Shehata   +8 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Patients’ and healthcare professionals’ views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study

Tobacco Induced Diseases, 2014
Background Hospital admission provides a powerful opportunity to promote smoking cessation. We explored patients’ and healthcare professionals’ (HCP) views of a specialist smoking cessation service comprising systematic smoking ascertainment, default ...
Manpreet Bains, John Britton, John Marsh, Leah Jayes, Rachael L Murray   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source