Results 121 to 130 of about 3,453,028 (352)
Oxyphil cells in secondary hyperparathyroidism
Journal of Japanese Society for Dialysis Therapy, 1987 近年, 慢性腎不全患者の2次性副甲状腺機能亢進症 (2°HPT) による腎性骨異栄養症に対する副甲状腺摘除術は有効な治療法とされ, その臨床効果も評価されている. しかし, その組織学的に詳細な検討, 特に好酸性細胞の機能に関する検討はなされていない. 副甲状腺の好酸性細胞は, 従来, 退行変性細胞であり, 内分泌的には非活動性のものとされていたが, その特性が明らかにされ, かつ, 好酸性細胞腺腫による原発性副甲状腺機能亢進症 (1°HPT) の症例が集積されるようになり, その機能性について言及されるようになってきている.今回我々は慢性血液透析施行中の5例に対して副甲状腺亜全摘術, あるいは副甲状腺全摘術+前腕筋肉内移植術を行い, 2°HPTにおける好酸性細胞の機能に関して組織学的観察を行った ...
Ibuki Yajima +2 more
openaire +2 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Rapid reactivation of extralymphoid CD4 T cells during secondary infection.
PLoS ONE, 2011 After infection, extralymphoid tissues are enriched with effector and memory T cells of a highly activated phenotype. The capacity for rapid effector cytokine response from extralymphoid tissue-memory T cells suggests these cells may perform a 'sentinel'
Timothy J Chapman +2 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue [PDF]
, 2021 Hua Tian +3 more
openalex +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
A rare case of hepatosplenic gamma‐delta T‐cell lymphoma and secondary hemophagocytic lymphohistiocytosis [PDF]
, 2018 Philip Brandt +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
T cell recognition of nonpolymorphic determinants on H-2 class I molecules. [PDF]
, 1988 Recognition of polymorphic determinants on class I or class II MHC Ag is required for T lymphocyte responses. Using cell-size artificial membranes (pseudocytes) bearing H-2 class I Ag it is demonstrated that T cells can, in addition, recognize ...
Goldstein, SA, Mescher, MF
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