Results 101 to 110 of about 2,231,961 (316)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo

, 2004
Strategies to enhance the immunogenicity of tumors are urgently needed. Although vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response, its efficiency as immunogen is poor.
Zimmermann, VS, Voll, Reinhard E., Turnay, Javier, Manfredi, Angelo A., Turnay, J, Dumitriu, IE, Voll, RE, Zimmermann, Valérie S, Angelo A. Manfredi, Bertling, Wolf, Rovere-Querini, P, Kalden, JR, Udo S. Gaipl, Herrmann, M, Attilio Bondanza, Gaipl, Udo S, Wolf Bertling, Bertling, W, Patrizia Rovere-Querini, Ingrid E. Dumitriu, Bondanza, Attilio, Stach, Christian M., Pöschl, E, Stach, Christian M, Gaipl, US, Javier Turnay, Herrmann, Martin, Martin Herrmann, Dumitriu, Ingrid E., Rovere-Querini, Patrizia, Christian M. Stach, Manfredi, Angelo A, Kalden, Joachim R, Valérie S. Zimmermann, Pöschl, Ernst, Stach, CM, Dumitriu, Ingrid E; id_orcid, Gaipl, Udo S., Joachim R. Kalden, Bondanza, A, Zimmermann, Valérie S., Voll, Reinhard E, Kalden, Joachim R., Reinhard E. Voll, Manfredi, AA, Ernst Pöschl   +45 more
core   +1 more source

145 Appendix Specific Deletion of Ephrin-B2 in Peripheral Endothelial Cells, but not in Heart Endocardial Cells Reveals an Essential Role of Ephrin-B2 in Peripheral

, 2014
Ephrin-B2 conventional knockout and endothelial specific knockout mice show the same angiogenesis defects in head, trunk and yolk sac as well as the same heart defects during embryonic development (Gerety and Anderson, 2002; Wang et al., 1998); ephrin-B2
Endothelial Cells
core  

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]

, 2004
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Beverley, Peter, Soarees, MV, Akbar, AN, Joanne E. Cook, Soares, MV, Rustin, MH, Cook, JE, Beverley, PC, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson   +31 more
core   +1 more source

Modeling CNS Involvement in Pompe Disease Using Neural Stem Cells Generated from Patient-Derived Induced Pluripotent Stem Cells

, 2020
Pompe disease is a lysosomal storage disorder caused by autosomal recessive mutations in the acid alpha-glucosidase (GAA) gene. Acid alpha-glucosidase deficiency leads to abnormal glycogen accumulation in patient cells.
Junjie Hong, Rong Li, Jeanette Beers, Yu-Shan Cheng, Shu Yang, Jizhong Zou, Wenwei Huang, Wei Zheng   +7 more
core   +1 more source

On a Perpetual Form of Secondary Cell [PDF]

Nature, 1882
I HAVE succeeded, after many fruitless attempts, in discovering an indestructible material which can be substituted for lead, as the negative or oxygen-bearing plate of the Faure accumulators, without sacrificing any of the extraordinary good qnalities which that excellent form of secondary couple possesses, excepting only its cheapness of construction.
openaire   +2 more sources

Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection

, 2010
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out.
Stephen E. Braun, Berger Annemarie, John J Rossi, Stephen E Braun, Kimpel, Janine, Conolle Michelle, Annemarie Berger, R Paul Johnson, Schmitz, Jörn E., Qiu Gang, Schmitz Jörn E., Qiu, Gang, John J. Rossi, Dorothee von Laer, Wong Fay Eng, Laer, Dorothee von, Boro Dropulic, Humeau, Laurent M., Humeau Laurent M., Christian Brendel, Conolle, Michelle, Brendel Christian, Michelle Conolle, Laurent M Humeau, Braun, Stephen E., Brendel, Christian, Jörn E Schmitz, Wong, Fay Eng, Janine Kimpel, Gang Qiu, Dropulic Boro, von Laer Dorothee, Berger, Annemarie, Jörn E. Schmitz, R. Paul Johnson, Rossi, John J., Rossi John J., Laurent M. Humeau, Fay Eng Wong, Johnson, R. PauL, Kimpel Janine, Braun Stephen E., Johnson R. Paul, Dropulic, Boro   +43 more
core   +1 more source

Virus-Specific Secondary Plasma Cells Produce Elevated Levels of High-Avidity Antibodies but Are Functionally Short Lived. [PDF]

, 2019
Most vaccines aim at inducing durable antibody responses and are designed to elicit strong B cell activation and plasma cell (PC) formation. Here we report characteristics of a recently described secondary PC population that rapidly originates from ...
Krüger, Caroline C., Bachmann, Martin F., Thoms, Franziska, Vogel, Monique, Keller, Elsbeth   +4 more
core   +1 more source

Oxyphil cells in secondary hyperparathyroidism

Journal of Japanese Society for Dialysis Therapy, 1987
近年, 慢性腎不全患者の2次性副甲状腺機能亢進症 (2°HPT) による腎性骨異栄養症に対する副甲状腺摘除術は有効な治療法とされ, その臨床効果も評価されている. しかし, その組織学的に詳細な検討, 特に好酸性細胞の機能に関する検討はなされていない. 副甲状腺の好酸性細胞は, 従来, 退行変性細胞であり, 内分泌的には非活動性のものとされていたが, その特性が明らかにされ, かつ, 好酸性細胞腺腫による原発性副甲状腺機能亢進症 (1°HPT) の症例が集積されるようになり, その機能性について言及されるようになってきている.今回我々は慢性血液透析施行中の5例に対して副甲状腺亜全摘術, あるいは副甲状腺全摘術+前腕筋肉内移植術を行い, 2°HPTにおける好酸性細胞の機能に関して組織学的観察を行った ...
Yajima, Ibuki, Yamasaki, Giichi, Enzan, Hideaki   +2 more
openaire   +2 more sources

Molars to Medicine: A Focused Review on the Pre-Clinical Investigation and Treatment of Secondary Degeneration following Spinal Cord Injury Using Dental Stem Cells

Spinal cord injury (SCI) can result in the permanent loss of mobility, sensation, and autonomic function. Secondary degeneration after SCI both initiates and propagates a hostile microenvironment that is resistant to natural repair mechanisms ...
Jillian Mary Clark, Sandra Jenkner, Stan Gronthos, Ryan Louis O’Hare Doig   +3 more
core   +1 more source