Results 281 to 290 of about 3,453,028 (352)

Validation and performance assessment of a commercial anti-peroxidasin antibody. [PDF]

Histochem Cell Biol
Brandão I, Silva R, Gomes B, Almeida JR, Oliveira JP, Alencastre IS.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Secondary <i>POLE</i> Mutation Drives Metastasis in Hereditary Breast and Ovarian Cancer: Revealing Fallopian Tube Ultramutation. [PDF]

JCO Precis Oncol
Jisaka M, Nakamura K, Chiyoda T, Iwata T, Masuda K, Kawano R, Funata S, Takamatsu R, Nishihara H, Yamagami W.   +9 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The development of a therapeutic strategy for post-acute sequelae of COVID-19 should be based on an efficient classification of pathogenesis. [PDF]

Front Med (Lausanne)
Wang H, Shen L, Xue S.
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Case Report: Secondary myelodysplastic syndrome following autologous stem cell transplantation in a patient with POEMS syndrome. [PDF]

Front Immunol
Le M, Dong N, Tan Z, Ye B, Chen J, Liu S.   +5 more
europepmc   +1 more source

Acute Myocardial Infarction Due to Nonbacterial Thrombotic Endocarditis in Advanced Intrahepatic Cholangiocarcinoma: A Case Report. [PDF]

Am J Case Rep
Ebina G, Tanaka S, Asonuma S, Suzuki H, Tomioka T.   +4 more
europepmc   +1 more source

Identification of novel regulators of LINE-1 expression via CRISPR/Cas9 screening. [PDF]

Mob DNA
Oksuz O, Chu C, Arisdakessian C, Diao L, Zaller D, Long KK, Keilhack H, Knutson S.   +7 more
europepmc   +1 more source