Results 41 to 50 of about 939,140 (300)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Enhancing Formal Assessment Using Concept Cartoons in Physics: A Teacher’s Perspective

Science Education International
Fostering methods that promote learners’ conceptual understanding is crucial for better performance in science subjects. This study investigated how teachers of physical sciences perceive the utilization of Concept Cartoons as a formative evaluation tool.
William Zivanayi, Chinelo Georgina Candy Nwaigwe   +1 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Teacher educational qualifications and the quality of teacher–student interactions in senior high school classrooms in Ghana: Could teacher self‐efficacy bridge the qualifications gap?

Future in Educational Research
Teacher qualifications, self‐efficacy, and quality of teacher–student interactions (QTSIs) are critical factors in educational discourse. While research shows varied results for each variable, studies have yet to examine all three variables ...
Albert Henry Ntarmah, Kwesi Yaro
doaj   +1 more source

The Ship in the Cave: The Greek and Nautical Origin of Buddhist Architecture

Journal of Asian Architecture and Building Engineering, 2020
Buddhist architecture rose during the time of the Greek influence in western India, but until today no relationship has been proved between both facts. If we accept that the Greeks stored their galleys overturning and placing them upon stanchions, as the
José M. Ciordia
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Secondary education

Revista de la Asociacion Medica Argentina, 2000
The main focus of this report is on education expenditure and participation. The indicator most frequently referred to in public debates on expenditure is the percentage of GDP per country on education. A serious problem with this indicator is that it is affected by enrolment rates and the size of the youth population. A more sophisticated indicator is
  +6 more sources

A survey on digital device engagement, digital stress, and coping strategies among college students in the Philippines

International Journal of Adolescence and Youth
This study surveyed 384 Filipino college students on their digital device engagement, digital stress, and coping strategies. Findings revealed that students were heavily reliant on digital devices.
Louie Giray, Jonard Nemeño, Jasmin Braganaza, Sheila May Lucero, Rex Bacarra   +4 more
doaj   +1 more source

Sustaining pedagogical change via faculty learning community

International Journal of STEM Education, 2019
Background The necessity of a science, technology, engineering, and math (STEM) literate population continues to be a high priority worldwide. One approach to build and bolster a STEM-literate workforce is to explore approaches for strengthening the ...
Teresa L. Tinnell, Patricia A. S. Ralston, Thomas R. Tretter, Mary E. Mills   +3 more
doaj   +1 more source