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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source

Teacher educational qualifications and the quality of teacher–student interactions in senior high school classrooms in Ghana: Could teacher self‐efficacy bridge the qualifications gap?

Future in Educational Research
Teacher qualifications, self‐efficacy, and quality of teacher–student interactions (QTSIs) are critical factors in educational discourse. While research shows varied results for each variable, studies have yet to examine all three variables ...
Albert Henry Ntarmah, Kwesi Yaro
doaj +1 more source

Enhancing Formal Assessment Using Concept Cartoons in Physics: A Teacher’s Perspective

Science Education International
Fostering methods that promote learners’ conceptual understanding is crucial for better performance in science subjects. This study investigated how teachers of physical sciences perceive the utilization of Concept Cartoons as a formative evaluation tool.
William Zivanayi, Chinelo Georgina Candy Nwaigwe +1 more
doaj +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source

Collective screening tools for early identification of dyslexia

Frontiers in Psychology, 2015
Current response to intervention models (RTI) favor a three-tier system. In general, Tier 1 consists of evidence-based, effective reading instruction in the classroom and universal screening of all students at the beginning of the grade level to identify
Olga Valéria Campana Dos Anjos Andrade +2 more
doaj +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source

Secondary education

Revista de la Asociacion Medica Argentina, 2000
The main focus of this report is on education expenditure and participation. The indicator most frequently referred to in public debates on expenditure is the percentage of GDP per country on education. A serious problem with this indicator is that it is affected by enrolment rates and the size of the youth population. A more sophisticated indicator is
+6 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source

Assessment of the economics of production of weaner and grower rabbit fed sunflower seed meal (SFSM) based diets with or without Ronoxyme® HiPhos enzyme

International Journal of Agricultural Research, Innovation and Technology
The cost-benefit analysis performance of weaner and grower rabbits fed processed sunflower (Helianthus annuus) seed meal (SFSM) and diets treated with enzymes in the research area was assessed.
Bosede Oluwatoyin Onazi +2 more
doaj +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source

teacher education