Results 101 to 110 of about 5,179,156 (340)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Prevention care for secondary health conditions among people living with spinal cord injuries: research protocol

BMC Research Notes, 2019
Objective People living with spinal cord injuries are at a high risk to experience preventable secondary health conditions in their lifetime, which can lead to rehospitalisation and death.
Sonti Pilusa, Hellen Myezwa, Joanne Potterton   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Health & Wellness Centers to Strengthen Primary Health Care in India: Concept, Progress and Ways Forward

Indian Journal of Pediatrics, 2020
In February 2018, the Indian Government announced Ayushman Bharat Program (ABP) with two components of (a) Health and Wellness Centres (HWCs), to deliver comprehensive primary health care (PHC) services to the entire population and (b) Pradhan Mantri Jan
C. Lahariya
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

GEOSPATIAL ANALYSIS OF PEDIATRIC TUBERCULOSIS IN BOHOL, PHILIPPINES: DISEASE CLUSTERS AND ACCESS TO CARE [PDF]

, 2019
Worldwide, children represent approximately 10% of global tuberculosis (TB) cases. We recently reported a high tuberculin skin test (TST)-positive prevalence (355/5,476; weighted prevalence=6.4%) among children (\u3c15 years) throughout the island of ...
LEINING, LAUREN M
core   +1 more source

Access to HIV care in the context of universal test and treat: challenges within the ANRS 12249 TasP cluster-randomized trial in rural South Africa [PDF]

, 2016
Introduction: We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal ...
Attia, Barnabas, Bassett, Cohen, Collins Iwuji, Danel, Doherty, Donnell, Fox, France Lert, François Dabis, Granich, Hatcher, Houlihan, Iwuji, Joanna Orne-Gliemann, Joseph Larmarange, Kamal El Farouki, Lundgren, MacPherson, Maheswaran, Marie-Louise Newell, Medley, Morris, Mugglin, Muloongo, Mélanie Plazy, Naik, Naik, Nakigozi, Nonhlanhla Okesola, Nsigaye, Orne-Gliemann, Rooyen, Rosemary Dray-Spira, Rosen, Tabana, Tanser, Wringe, Zaidi   +39 more
core   +6 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Young People's mental health service utilization

International Journal of Population Data Science
Objective This project aimed to uncover key factors that shape young people’s (YP) mental health care utilization. The Andersen’s Behavioral Model of Health Care Utilization was adapted in co-production, providing a framework for the predisposing ...
Corine Driessens, Peter W.F. Smith, Kim Markham-Jones, Fiona Lacey   +3 more
doaj   +1 more source

Quality of outpatient nursing care: a scoping review [PDF]

Revista Latino-Americana de Enfermagem
Objective: to map national and international scientific literature on the quality of outpatient nursing care. Method: a scoping review guided by the Joanna Briggs Institute Collaboration, conducted across 12 databases and repositories.
Bruna Noschang de Brum, Carlise Rigon Dalla Nora, Adriana Roese Ramos, Luciana Foppa, Deise Lisboa Riquinho   +4 more
doaj   +1 more source