Results 131 to 140 of about 54,493 (255)

Role of Notch signaling in fibroblasts of secondary lymphoid organs

, 2019
Spleen and lymph nodes (LN) are compartmentalized into functionally distinct microenvironments, which are thought to optimize antigen presentation to naïve recirculating lymphocytes. These microenvironments are formed to a large extent by fibroblasts: Follicular Dendritic Cells (FDC) in the B cell follicles with the remaining fibroblasts being ...
openaire   +2 more sources

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development. [PDF]

Front Immunol
Köstel Bal S, Haskoloğlu Ş, Ransmayr B, Sevinç S, İslamoğlu C, Baskın K, Deveci N, Savaş B, Fitoz S, Küpesiz A, Kendirli T, Boztug K, Doğu F, İkincioğulları KA.   +13 more
europepmc   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Retrospective evaluation of palliative care consultation in critically ill adult and pediatric cancer subjects

Pediatric Investigation, EarlyView.
Children with cancer received more palliative care consultation before, but fewer during, critical illness compared with adults. This disparity suggests underuse of palliative care during pediatric critical care. ABSTRACT Importance Palliative care consultation is an essential component of comprehensive care for patients with cancer during critical ...
Conrad Krawiec, Neal Thomas
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Biomimetic TME‐Responsive Nanotheranostics for Precise NIR‐II Ratiometric Photoacoustic Imaging and Synergistic Immuno‐Photothermal Therapy

Small, EarlyView.
A biomimetic Au/Ag@HMON‐NLG@CCM nanotheranostic is engineered for tumor microenvironment‐responsive NIR‐II ratiometric photoacoustic imaging and immune‐photothermal therapy. The integration of hyperthermia‐triggered immunogenic cell death with IDO‐blockade‐mediated metabolic remodeling promotes dendritic cell maturation and T‐cell activation.
Xin Li, Hongrui Qiu, Lik Hang Hugo Tse, Xuehan Wang, Hsuan Lo, Huili Wang, Qi Li, Shiying Li, Yanjuan Gu, Wing‐tak Wong   +9 more
wiley   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, EarlyView.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Secondary lymphoid organ homing phenotype of human myeloid dendritic cells disrupted by an intracellular oral pathogen. [PDF]

Infect Immun, 2014
Miles B, Zakhary I, El-Awady A, Scisci E, Carrion J, O'Neill JC, Rawlings A, Stern JK, Susin C, Cutler CW.   +9 more
europepmc   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source