Results 121 to 130 of about 1,354,653 (354)

Induction of microbial secondary metabolism [PDF]

, 2010
Precursors often stimulate production of secondary metabolites either by increasing the amount of a limiting precursor, by inducing a biosynthetic enzyme (synthase) or both.
Arnold L. Demain
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Influence on Secondary Metabolism of Piper nigrum L. by Co-Inoculation with Arbuscular Mycorrhizal Fungi and Fusarium solani f. sp. piperis [PDF]

, 2021
Rafaela Da Trindade, Laís Bentes de Almeida, Luciana Pereira Xavier, Eloísa Helena de Aguiar Andrade, José Guilherme S. Maia, Andréa Hentz de Mello, William N. Setzer, Alessandra Ramos, Joyce Kelly R. da Silva   +8 more
openalex   +1 more source

A suggested prototype for assessing bone health [PDF]

, 2015
Background- Osteoporosis is becoming a health concern worldwide. Considering the fact that prevention plays an important role in reducing the burden of this silent disease and in view of the limited resources available, many countries have adopted ...
Aghaei Meybodi, H.-D., Bayegi, F., Derakhshan, S., Dini, M., Ebrahimi, M., Etemad, K., Hajian, M., Jouyandeh, Z., Karimi, M., Keshtkar, A., Khashayar, P., Larijani, B., Mohammadi, Z., Nabavi, H., Ramezani, M., Razi, F., Sadigh, H., Saghafi, S.   +17 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer

Biomolecules
RNA interference (RNAi) holds promise as a gene-silencing therapy for liver cancer but faces challenges related to siRNA instability, short half-life, and inefficient cellular uptake.
Shuyi Sun, Ling Yan, Zhekai Liu, Weibo Jin   +3 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Differential transcript profiling alters regulatory gene expression during the development of Gossypium arboreum, G.stocksii and somatic hybrids

Scientific Reports, 2017
Polyploidy or genome doubling (i.e., the presence of two or more diploid parental genome sets within an organism) are very important in higher plants.
Liping Ke, Binglun Luo, Liqing Zhang, Mengna Zhang, Xiushuang Yu, Jie Sun, Yuqiang Sun   +6 more
doaj   +1 more source

Enhanced Secondary- and Hormone Metabolism in Leaves of Arbuscular Mycorrhizal Medicago truncatula [PDF]

, 2017
Lisa Adolfsson, Hugues Nziengui, Ilka N. Abreu, Jan Šimura, Azeez Beebo, Andrei Herdean, Jila Aboalizadeh, Jitka Široká, Thomas Möritz, Ondřej Novák, Karin Ljung, Benoı̂t Schoefs, Cornelia Spetea   +12 more
openalex   +1 more source

Comparative genomic analysis of Flavobacteriaceae: insights into carbohydrate metabolism, gliding motility and secondary metabolite biosynthesis. [PDF]

, 2020
Asimenia Gavriilidou, Johanna Gutleben, Dennis Versluis, Francesca Forgiarini, Mark WJ van Passel, Colin J. Ingham, Hauke Smidt, Detmer Sipkema   +7 more
openalex   +1 more source