Results 201 to 210 of about 219,209 (310)

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production. [PDF]

Metabolites
Li Y, Zhang Y, He X, Guo Z, Yang N, Bai G, Zhao J, Xu D.   +7 more
europepmc   +1 more source

SECONDARY METABOLITES OF OCIMUM GRATISSIMUM AND THEIR BIOLOGICAL ACTIVITIES

, 2013
Deeptanjali Sahoo, Ajay Kumar
openalex   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Drought, herbivory and combined stress caused treatment-specific changes in phytohormones, but species-specific changes in secondary metabolite profiles in thyme. [PDF]

Front Plant Sci
Alipour M, Martinelli L, Groten K, Mithöfer A.   +3 more
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Comprehensive genome analysis of <i>Burkholderia gladioli</i> BGLCN isolated from rice seedlings in Thailand reveals potential for secondary metabolite production. [PDF]

Data Brief
Patarapuwadol S, Nualnisachol P, Premsuriya J.   +2 more
europepmc   +1 more source

Enhanced Antioxidant Activity and Secondary Metabolite Production in Tartary Buckwheat under Polyethylene Glycol (PEG)-Induced Drought Stress during Germination [PDF]

Md Shakhawat Hossain, Jing Li, Chenyang Wang, Fakhrul Islam Monshi, Rehenuma Tabassum, Md Ashraful Islam, Muhiuddin Faruquee, Md Abdul Muktadir, Md Sultan Mia, A. K. M. Mominul Islam, Ahmed Khairul Hasan, Ashim Sikdar, Baili Feng   +12 more
openalex   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Physiological and metabolic responses of Bacopa monnieri to salt-induced stress: implications for secondary metabolite elicitation. [PDF]

BMC Plant Biol
Taratima W, Trunjaruen A, Kaenpho K, Maneerattanarungroj P, Kunpratum N.   +4 more
europepmc   +1 more source