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Engineering of secondary metabolite pathways
Current Opinion in Biotechnology, 2003Nature produces an astonishing wealth of secondary metabolites with important biological functions. To access this diversity of structurally complex chemical compounds for industrial and biomedical applications, cells have been engineered to produce higher levels and/or novel compounds that were previously inaccessible. Recent examples of metabolic and
Benjamin N, Mijts +1 more
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Secondary metabolites from Ganoderma
Phytochemistry, 2015Ganoderma is a genus of medicinal mushrooms. This review deals with secondary metabolites isolated from Ganoderma and their biological significance. Phytochemical studies over the last 40years led to the isolation of 431 secondary metabolites from various Ganoderma species. The major secondary compounds isolated are (a) C30 lanostanes (ganoderic acids),
Sabulal Baby +2 more
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Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1996
SynopsisAll plants expend energy and nutrients in the production of secondary metabolites. Ecosystem-level studies on the production of metabolites in African rain forests are reviewed and factors influencing the production and distribution of phenolic compounds discussed.
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SynopsisAll plants expend energy and nutrients in the production of secondary metabolites. Ecosystem-level studies on the production of metabolites in African rain forests are reviewed and factors influencing the production and distribution of phenolic compounds discussed.
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Extraction of Plant Secondary Metabolites
2006This chapter presents an overview of the preparation of extracts from plants using organic solvents, with emphasis on common problems encountered and methods for their reduction or elimination. In addition to generally applicable extraction protocols, methods are suggested for selectively extracting specific classes of plant-derived compounds, and ...
William P, Jones, A Douglas, Kinghorn
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Molecular recognition by secondary metabolites
Biochemical Pharmacology, 1990Aspects of molecular recognition based on the interaction between the vancomycin group of antibiotics and bacterial cell wall precursor analogues are discussed. The energetically unfavourable folding-in of the residue 1 sidechain in vancomycin and ristocetin A is discussed in terms of the favourable entropy associated with simultaneous release of ...
D H, Williams +3 more
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2020
Secondary metabolites are organic compounds produced by microorganism or plant which are not directly involved in the growth, development, or reproduction of the organism. Secondary metabolites play an important role in plant defense against insects and microorganisms defenses. Humans use to secondary metabolites in medicines, flavorings, pigments, and
TİRİNG, Gülsevim +2 more
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Secondary metabolites are organic compounds produced by microorganism or plant which are not directly involved in the growth, development, or reproduction of the organism. Secondary metabolites play an important role in plant defense against insects and microorganisms defenses. Humans use to secondary metabolites in medicines, flavorings, pigments, and
TİRİNG, Gülsevim +2 more
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Detection of Novel Secondary Metabolites
Critical Reviews in Biotechnology, 1991The study of antibiotics and other fermentation products has shown that a seemingly unlimited number of compounds with diverse structures are produced by microorganisms. The continued high rate of discovery of new chemical entities, in the light of the abundance of microbial products already described, is due to creative screening procedures that ...
C M, Franco, L E, Coutinho
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Production of Secondary Metabolites by Bioconversion
2007The omnipotency (omnis = all, potens = powerful) of the plant cell implies that all genetic information present in the plant is principally available in each cell. This means that genes encoding enzymes that belong to biosynthetic pathways can be brought to expression.
Pras, Niesko, Woerdenbag, Herman J.
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Redox active secondary metabolites
Current Opinion in Chemical Biology, 2011Various secondary metabolites from plants, bacteria and fungi are redox active and able to modulate the intracellular redox equilibrium in living cells. Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell death.
Claus, Jacob +2 more
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Unexpected applications of secondary metabolites
Biotechnology Advances, 2011Secondary metabolites have been found to have interesting applications over and above their well-known medical uses, e.g., as antimicrobials, etc. These alternative applications include antitumor, cholesterol-lowering, immunosuppressant, antiprotozoal, antihelminth, antiviral and anti-ageing activities.
Preeti, Vaishnav, Arnold L, Demain
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