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Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

open access: yesAdvanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang   +7 more
wiley   +1 more source
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Microbial Secondary Metabolites

2011
More than 20,000 bioactive, so-called microbial secondary metabolites are known today. In nature, they can play many different roles, such as antibiotics, toxins, ionophores, bioregulators, and in intra- and interspecific signaling. Their most versatile producers are differentiating filamentous fungi and actinomycetes, followed by other bacteria, such ...
Marinelli F., Marcone G. L.
openaire   +2 more sources

Secondary Metabolites

Alzheimer's, Parkinson's, and various neurodegenerative diseases are generally characterized by neuronal loss, which directly induces cognitive and motor dysfunctions. Secondary metabolites, as natural products of aromatic and medicinal plants and other origins, could present a promising alternative source to combat neurodegenerative diseases.
Adil El Housseini   +11 more
  +4 more sources

Transporters of secondary metabolites

Current Opinion in Plant Biology, 2005
The membrane transport of plant secondary metabolites is a newly developing research area. Recent progress in genome and expressed sequence tag (EST) databases has revealed that many transporters and channels exist in plant genome. Studies of the genetic sequences that encode these proteins, and of phenotypes caused by the mutation of these sequences ...
openaire   +2 more sources

Plant Secondary Metabolites

2015
Secondary metabolites are those compounds which are produced by certain microorganisms in a phase of subsequent to growth, may have some survival function, have unusual chemical structures, and are formed as mixtures of closely related members of a chemical family.
openaire   +2 more sources

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