Results 231 to 240 of about 375,474 (296)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Soil microorganism colonization influenced the growth and secondary metabolite accumulation of Bletilla striata (Thunb.) Rchb. F. [PDF]

BMC Microbiol
Xu Q, Fu Y, Zhang J, Xu C, Yang C, Yuan Q, Xu J, Jiang W, Zhang Y, Zhou T, Xiao C.   +10 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Medicinal plants in a changing climate: understanding the links between environmental stress and secondary metabolite synthesis. [PDF]

Front Plant Sci
Jangpangi D, Patni B, Chandola V, Chandra S.   +3 more
europepmc   +1 more source

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Advanced Science, EarlyView.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun, Ruixiang You, Yiwen Zhou, Huiyan He, Wenfang Wang, Xudong Qu, Yinhua Lu, Lei Li   +7 more
wiley   +1 more source

Novel Gene Clusters for Secondary Metabolite Synthesis in Mesophotic Sponge-Associated Bacteria. [PDF]

Microb Biotechnol
Chen N, Liu L, Wang J, Mao D, Lu H, Shishido TK, Zhi S, Chen H, He S.   +8 more
europepmc   +1 more source

New approaches to secondary metabolite discovery from anaerobic gut microbes. [PDF]

Appl Microbiol Biotechnol
Butkovich LV, Vining OB, O'Malley MA.
europepmc   +1 more source

Co-Culture with Two Soil Fungal Strains Enhances Growth and Secondary Metabolite Biosynthesis in <i>Cordyceps takaomontana</i>. [PDF]

J Fungi (Basel)
Chen J, Ding M, He D, Zhang D, Wang M, Xiang Y, Liu T.   +6 more
europepmc   +1 more source

Corrigendum: Modulation of pulmonary immune functions by the <i>Pseudomonas aeruginosa</i> secondary metabolite pyocyanin. [PDF]

Front Immunol
Lew SQ, Chong SY, Lau GW.
europepmc   +1 more source