Results 201 to 210 of about 3,826,489 (355)

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Manipulation of rumen fermentation and methane production with plant secondary metabolites [PDF]

, 2012
Raúl Bodas, N. Prieto, R. García-González, Sonia Andrés, Francisco Javier Giráldez, Secundino López   +5 more
openalex   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

The Current State of Knowledge About Changes in the Synthesis of the Secondary Metabolites Caused by Habitat Conditions and Microbial Activity [PDF]

Barbara Bacler-Żbikowska, Agnieszka Hutniczak, Barbara Pilawa, Ewa Chodurek, Magdalena Zdybel, Anna Piekarska‐Stachowiak, Dea Fatmawati, Leszek Malinowski, Gabriela Woźniak   +8 more
openalex   +1 more source

SECONDARY METABOLITES FROM RICE CULTURE OF ASPERGILLUS SP. ISOLATED FROM MELALEUCA SUBULATA (CHEEL) CRAVEN LEAVES AND THEIR ANTICANCER ACTIVITY

, 2020
Haitham A. Ibrahim, Reham R. Ibrahim, Reem A. Kamel, Shahenda M. El‐Messery, Fatma A. Moharram   +4 more
openalex   +1 more source

Temporal Trends in the Secondary Metabolite Production of the Sponge Aplysina aerophoba [PDF]

, 2012
Oriol Sacristán‐Soriano, Bernard Banaigs, Mikel A. Becerro   +2 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Dietary Stress From Plant Secondary Metabolites Contributes to Grasshopper (Oedaleus asiaticus) Migration or Plague by Regulating Insect Insulin-Like Signaling Pathway

, 2019
Shuang Li, Xunbing Huang, M.R. McNeill, Wen Liu, Xiongbing Tu, Jingchuan Ma, Shenjin Lv, Zehua Zhang   +7 more
openalex   +1 more source

CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria.

Water Research, 2021
Martin R. Jones, E. Pinto, Mariana A. Torres, F. Dörr, H. Mazur-Marzec, Karolina Szubert, L. Tartaglione, C. Dell’Aversano, C. Miles, Daniel G. Beach, P. McCarron, K. Sivonen, D. Fewer, J. Jokela, E. Janssen   +14 more
semanticscholar   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source