Results 241 to 250 of about 3,826,489 (355)

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Secondary Metabolites Predict Diazotrophic Cyanobacteria: A Model-Based Cheminformatic Approach. [PDF]

Metabolites
Young J, Nawaz T, Gu L, Zhou R.
europepmc   +1 more source

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

New bioactive secondary metabolites from fungi: 2024. [PDF]

Mycology
Bao M, Shi Y, Gong X, Guo Y, Wang J, Chen X, Liu L.   +6 more
europepmc   +1 more source

Bioactive secondary metabolites from two sponge-derived actinomycetes

, 2022
Zhi‐Kai Guo, Rong Wang, Weicheng WU, Ming Li, Wanggui HE, Shilin ZHOU   +5 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Antioxidant and Photoprotective Capacity of Secondary Metabolites Isolated from <i>Pseudocyphellaria berberina</i>. [PDF]

Molecules
Rubio C, Ramírez J, Rojas JL, Valencia-Islas NA, Campos C, Quiñones N.   +5 more
europepmc   +1 more source

Molecular Chain Elongation Mechanism for n‐Caproate Biosynthesis by Megasphaera Hexanoica

Advanced Science, EarlyView.
The medium‐chain carboxylate‐producing microbe Megasphaera hexanoica is analyzed through genomics, transcriptomics, and metabolic engineering. The n‐caproate biosynthetic pathway is reconstructed in Escherichia coli, highlighting MhTHL as a key β‐ketothiolase. Structural analysis and mutagenesis reveal that MhTHL has a distinct substrate‐binding pocket,
Byoung Seung Jeon, Eun‐Jung Kim, Hogyun Seo, Hyunjin Kim, Seungjin Shin, Caroline Schlaiß, Largus T. Angenent, Kyung‐Jin Kim, Byoung‐In Sang   +8 more
wiley   +1 more source

Differential accumulation of secondary metabolites as indicators of graft incompatibility in Cyclocarya paliurus. [PDF]

Sci Rep
Caowen S, Run X, Xuchen G, Xulan S, Shengzuo F.   +4 more
europepmc   +1 more source

Genomic and Multi-Omics Analysis of Phlebopus portentosus: Effects of Cultivation on Secondary Metabolites [PDF]

Zihong Kang, Xiaolong Yuan, Chuanguang Zhang, Yi Wang, Lu Li, Yuan Zheng   +5 more
openalex   +1 more source