Results 31 to 40 of about 361,714 (259)

Secondary Metabolites from the Fungus

Natural Product Communications, 2013
A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans , together with koninginin E (2), koninginin A (3), trichodermatide B (4), citrantifidiol (5), (4 S ,5 R )-4-hydroxy-5-methylfuran-2-one (6), the glycerol
Amer H. Tarawneh, Francisco León, Mohamed M. Radwan, Luiz H. Rosa, Stephen J. Cutler   +4 more
doaj   +1 more source

Secondary Metabolites from Rubiaceae Species

Molecules, 2015
This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae,
Daiane Martins, Cecilia Veronica Nunez
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spring Abundance, Migration Patterns and Damaging Period of Aleyrodes proletella in the Czech Republic

Agronomy
The cabbage whitefly has become an important pest on brassica vegetables in Central Europe. It does not destroy the affected plants, but the product becomes unmarketable, causing considerable economic losses.
Kamil Holý, Kateřina Kovaříková
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Two New Secondary Metabolites from

Natural Product Communications, 2015
Further investigation of Tephrosia purpurea led to the isolation of a new prenylated flavone, isoglabratephrin B (1) and a new 1,2-ethanedione benzofuran derivative, purpdione B (2) .
Yin-Ning Chen, Yan Peng, Cheng-Hai Gao, Tao Yan, Zhi-Fang Xu, Samuel X. Qiu, Wen-Hao Cao, Ligao Deng, Ri-Ming Huang   +8 more
doaj   +1 more source

Insecticidal Activity of Plant Secondary Metabolites

Plants, 2022
Plant-insect interactions are one of the most fascinating fields of research attracting biologists, entomologists, botanists, as well as a wide range of multidisciplinary researchers [...]
Giovanni Benelli, Filippo Maggi
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Secondary Metabolites from the Liverwort

Natural Product Communications, 2009
A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2–11) and four aromatic compounds (13–16), were isolated from the liverwort Ptilidium ...
Dong-Xiao Guo, Yu Du, Yan-Yan Wang, Ling-Mei Sun, Jian-Bo Qu, Xiao-Ning Wang, Hong-Xiang Lou   +6 more
doaj   +1 more source