Results 101 to 110 of about 26,876 (262)

Health Promotion for People With Disabilities: The Emerging Paradigm Shift From Disability Prevention to Prevention of Secondary Conditions [PDF]

, 1999
James H. Rimmer
openalex   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

Ongoing epidemic of scarlet fever in Shanghai and the emergence of M1UK lineage group A Streptococcus: a 14-year surveillance study across the COVID-19 pandemic periodResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: The surge of group A Streptococcus (GAS) infections in regional countries warranted attention in the post-COVID-19 era. The resurgence of notifiable scarlet fever in China has been a public health issue since 2011.
Jiehao Cai, Xingyu Zhou, Chi Zhang, Yue Jiang, Panpan Lv, Yibin Zhou, Mingliang Chen, Mei Zeng   +7 more
doaj   +1 more source

Secondary prevention after cerebral ischaemia of presumed arterial origin: is aspirin still the touchstone? [PDF]

, 1999
Ale Algra, J. van Gijn, Ale Algra, Peter J. Koudstaal   +3 more
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Primary and Secondary Prevention of Strokes

Медицинский вестник Юга России, 2012
We have made an attempt to systematize risk factors of primary and repeated ischemic strokes development. The divisions of the corrected and not corrected have been introduced in basis of systematization.
N. A. Fomina-Chertousova, K. A. Bondarenko   +1 more
doaj  

Secondary prevention of stroke [PDF]

Australian and New Zealand Journal of Medicine, 1995
openaire   +3 more sources

Secondary prevention after myocardial infarction: still a long way to go [PDF]

, 1997
J Soler-Soler, G. Permanyer‐Miralda
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source