Results 111 to 120 of about 4,919,522 (294)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Primary and Secondary Prevention of Obesity

Journal of Education, Health and Sport
Introduction and purpose: Obesity is a persistent and recurring chronic condition marked by an excessive accumulation of body fat, which can deteriorate health, heighten the risk of complications, and shorten life expectancy.This review provides a ...
Aleksandra Kiełczewska, Grzegorz Szcześniak, Anna Kiełczewska   +2 more
doaj   +1 more source

Oregon injury prevention plan, 2011-2015

, 2012
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on April 30, 2015)."September ...

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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The percutaneous treatment of Patent Foramen Ovale, an effective and safe therapeutic choice

Open Medicine, 2013
Evola S., Trovato R., Kauroo B., Alioto L., Sucato V., Quagliana A., Magro S., Tona R., Novo G., Andolina G., Assennato P., Novo S.   +11 more
doaj   +1 more source

Antithrombotic therapy for long-term secondary prevention of acute coronary syndrome in high-risk patients

, 2015
Steen Husted1,2 1Department of Biomedicine, Centre for Clinical Pharmacology, Aarhus, 2Department of Medicine, Hospital Unit West, Herning, Denmark Abstract: Patients with acute coronary syndrome (ACS) represent a major clinical burden, because they ...
Husted S
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Income level is associated with differences in primary and secondary stroke prevention in China

Introduction The aim of this study was to assess differences in the effects of income level on the primary and secondary prevention of stroke in the Chinese population.
Yunzhi Wang, Liyuan Pu, Liyuan Han, Xiaojie Wang, Xu Guo, Tian Zhao, Fangfang Zeng, Chang Shu, Qiang Li, Junrong Ma, Ruijie Zhang, Huiming Ren   +11 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source