Results 101 to 110 of about 886,500 (301)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Use of Antiplatelets for Primary and Secondary Prevention of Cardiovascular Events in the Medical Outpatient Setting of a Tertiary Centre in Nigeria: A Six-Month Review

Nigerian Journal of Medicine
Background: Cardiovascular disease (CVD) is the leading cause of death globally. The use of antiplatelets in the secondary prevention of CVD is well established. Their role in primary prevention of CVD is uncertain.
Uzoma Chukwunonso Okechukwu, Chinweuba Michael Abonyi, Christian Chukwuemeka Eze   +2 more
doaj   +1 more source

Antithrombotic therapy for long-term secondary prevention of acute coronary syndrome in high-risk patients

, 2015
Steen Husted1,2 1Department of Biomedicine, Centre for Clinical Pharmacology, Aarhus, 2Department of Medicine, Hospital Unit West, Herning, Denmark Abstract: Patients with acute coronary syndrome (ACS) represent a major clinical burden, because they ...
Husted S
core  

Income level is associated with differences in primary and secondary stroke prevention in China

Introduction The aim of this study was to assess differences in the effects of income level on the primary and secondary prevention of stroke in the Chinese population.
Yunzhi Wang, Liyuan Pu, Liyuan Han, Xiaojie Wang, Xu Guo, Tian Zhao, Fangfang Zeng, Chang Shu, Qiang Li, Junrong Ma, Ruijie Zhang, Huiming Ren   +11 more
core   +1 more source

Reflecting on primary prevention of violence against women: the public health approach [PDF]

, 2014
Provides reflections on Australia\u27s efforts in primary prevention of violence against women and offers suggestions for the next steps to continue the momentum.
Inara Walden, Liz Wall
core  

Suicide Prevention Strategies: Case Studies from across the Globe

, 2011
This chapter contains sections titled: Abstract Introduction Model of Primary, Secondary, and Tertiary Prevention The Institute of Medicine (IOM) Model Suicide Prevention Programmes and Actions across the Globe Dilemma of Evidence‐Based Suicide ...
Christina W. Hoven, Camilla Wasserman, Wasserman, D, Wasserman, C, Hadlaczky, G,, Mandell, DJ, Gergö Hadlaczky, Donald J. Mandell, Danuta Wasserman, Hoven, CW   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Antiplatelet therapy for secondary prevention of coronary artery disease.

, 2014
The choice and duration of antiplatelet therapy for secondary prevention of coronary artery disease (CAD) is determined by the clinical context and treatment strategy.
Windecker, Stephan, Pilgrim, Thomas
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genomic analysis of multidrug-resistant Salmonella enterica Serovar Montevideo isolates in China

BMC Genomics
Background As an important foodborne bacterium, non-typhoidal Salmonella (NTS) is estimated to cause approximately 215,000 deaths worldwide each year. Globally, S.
Zhenhua Liu, Qiang Wang, Wenqing Wang, Jin Ding, Panpan Lv, Yue Jiang, Xuzhi Wang, Yue Liu, Chengjie Zhang, Chi Zhang, Lingfei Luo, Yibin Zhou, Xuebin Xu, Mingliang Chen   +13 more
doaj   +1 more source