Results 91 to 100 of about 886,500 (301)

Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis

, 2017
Ping Zhong,1,2,* Danhong Wu,3,* Xiaofei Ye,4 Ying Wu,2 Tuming Li,2 Shuwen Tong,2 Xueyuan Liu1,5 1Department of Neurology, Shanghai Tenth People’s Hospital, Nanjing Medical University, 2Department of Neurology, Shanghai Traditional Chinese and ...
Liu X, Tong S, Zhong P, Li T, Wu D, Ye X, Wu Y   +6 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

SCREENING: THE CORNERSTONE FOR SECONDARY PREVENTION

Gomal Journal of Medical Sciences, 2018
Screening test sorts out from apparently healthy population those who probably have the disease or risk factor. Screening test is quick, less accurate, inexpensive and simple to be conducted by technicians, thereby saving doctors time who only interprets
Iftikhar Ahmad
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Who needs secondary prevention?

, 2017
: Secondary prevention for ischaemic heart disease can be defined as a comprehensive set of measures, aiming to reduce the recurrence of cardiovascular disease and to improve long-term prognosis.
Frederix, Ines, Schmid, Jean-Paul, Paul Dendale, Dendale, Paul, Jean-Paul Schmid, Ines Frederix   +5 more
core   +1 more source

Attitude to Secondary Prevention and Concerns about Colonoscopy Are Independent Predictors of Acceptance of Screening Colonoscopy [PDF]

, 2010
Background: Colonoscopy in combination with endoscopic polypectomy has been shown to be an efficient measure for reducing colorectal cancer incidence.
Schubring-Giese, Bodo, Kolligs, Frank Thomas, Ziegler, Matthias, Bühner, Markus   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Standardization and quality improvement of secondary prevention through cardiovascular rehabilitation programmes in Europe: The avenue towards EAPC accreditation programme : a position statement of the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology (EAPC)

, 2020
Copyright © 2020 by European Society of CardiologyDespite the proven efficacy and cost-effectiveness of contemporary cardiovascular rehabilitation programmes, the referral to/uptake of and adherence to cardiovascular rehabilitation remains inadequate. In
Dendale, Paul, Doherty, Patrick, Ambrosetti, Marco, Abreu, Ana, Frederix, Ines, Voeller, Heinz, Piepoli, Massimo Francesco, Janssen, Arne, Davos, Constantinos, Janssens, Arne, Davos, Constantinos H., Piepoli, Massimo F., Völler, Heinz, Völler, Heinz (Prof. Dr.)   +13 more
core   +1 more source

Cost-Utility Analysis of Eprosartan Compared to Enalapril in Primary Prevention and Nitrendipine in Secondary Prevention in Europe-The HEALTH Model [PDF]

, 2009
Schwander B, Gradl B, Zoellner Y, et al. Cost-Utility Analysis of Eprosartan Compared to Enalapril in Primary Prevention and Nitrendipine in Secondary Prevention in Europe-The HEALTH Model. VALUE IN HEALTH.
Villar, Fernando Antoñanzas, Zöllner, York, Lueders, Stephan, Schwander, Björn, Lüders, S., Schrader, Joachim, Schwander, B., Greiner, W., Villar, F.A. [0000-0001-6122-9130], Schwander, Bjoern, Diener, Hans-Christoph, Schrader, J., Greiner, Wolfgang, Zöllner, Y., Diener, H.-C., Zoellner, York, Antonanzas Villar, Fernando, Gradl, B., Lindgren, P., Lüders, Stephan, Jönsson, B., Gradl, Birgit, Lindgren, Peter, Jonsson, Bengt   +23 more
core   +1 more source